IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases
Abstract
The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell-mediated responses in inflammation for more than a decade after it was first identified. Discovery of the cytokine IL-23, which shares a common p40 subunit with IL-12, prompted efforts to clarify the relative contribution of these two cytokines in immune regulation. Ustekinumab, a therapeutic agent targeting both cytokines, was recently approved to treat psoriasis...
Paper Details
Title
IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases
Published Date
Jun 29, 2015
Journal
Volume
21
Issue
7
Pages
719 - 729
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Notes
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