Original paper
Blockade of eosinophil migration and airway hyperresponsiveness by cPLA2-inhibition
Abstract
We examined the role of a cytosolic phospholipase A2 (cPLA2) in antigen-induced eosinophil infiltration of airways and in airway hyperresponsiveness to methacholine. Inhibition of cPLA2, or blockade of the platelet-activating factor (PAF) receptor, blocked antigen-induced airway hyperresponsiveness and suppressed eosinophil infiltration. Neither cyclooxygenase nor 5-lipoxygenase inhibition had either effect. We show here that, in...
Paper Details
Title
Blockade of eosinophil migration and airway hyperresponsiveness by cPLA2-inhibition
Published Date
Feb 1, 2001
Journal
Volume
2
Issue
2
Pages
145 - 149
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Notes
History