Last. D L Gibbons('KCL': King's College London)H-Index: 19
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Despite extensive studies into severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the effect of maternal infection on the neonate is unclear. To investigate this, we characterized the immunology of neonates born to mothers with confirmed SARS-CoV-2 infection during pregnancy. Here we show that maternal SARS-CoV-2 infection affects the neonatal immune system. Despite similar proportions of B cells, CD4+ T cells and CD8+ T cells, increased percentages of natural killer cells, Vδ2+ γδ T ...
There is limited understanding of the viral antibody fingerprint following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children. Herein, SARS-CoV-2 proteome-wide immunoprofiling of children with mild/moderate or severe coronavirus disease 2019 (COVID-19) versus multisystem inflammatory syndrome in children versus hospitalized control patients revealed differential cytokine responses, IgM/IgG/IgA epitope diversity, antibody binding and avidity. Apart from spike and n...
In the originally published version of this Article, there was an error in Extended Data Fig. 10c. Specifically, in Extended Data Fig. 10c, third panel to the right, the y-axis label (In CD4+ cells (%)) was incorrect. The correct label has been amended to read: “In CD4+ CXCR5+cells (%).” The change has been made to the online version of the Article.
Last. Florian Mair(Fred Hutchinson Cancer Research Center)H-Index: 18
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High-dimensional cytometry experiments measuring 20–50 cellular markers have become routine in many laboratories. The increased complexity of these datasets requires added rigor during the experimental planning and the subsequent manual and computational data analysis to avoid artefacts and misinterpretation of results. Here we discuss pitfalls frequently encountered during high-dimensional cytometry data analysis and aim to provide a basic framework and recommendations for reporting and analyzi...
Type I interferon response to systemic infections after head trauma or stroke impairs angiogenesis in injured tissues and may contribute to secondary neurological injury.
Systems approaches applied to human and nonhuman primate cohorts revealed that the transcription factor CREB1 (cAMP-responsive element-binding protein 1) may be a key driver of human immunodeficiency virus 1 vaccine-induced immunity.
Environmental allergens trigger activation of the ripoptosome in epithelial cells, which mediates the initial allergic response via intracellular processing and release of the alarmin IL-33 and represents a newly identified mechanism for epithelial allergen sensing.
Corbett et al. use the rhesus macaque model to evaluate the ability of the mRNA-1273 (Moderna) COVID-19 vaccine to protect against challenge with the antibody-evading Beta variant of SARS-CoV-2. Their key finding is that the vaccine prevents severe lung pathology, principally because it is able to induce a strong enough antibody resistance to overcome the variant’s relative resistance.