Effect of long-term treatment of morphine on enzymes, oxidative stress indices and antioxidant status in male rat liver.

In this study, biochemical changes due to long term usage of morphine in rat's liver were assessed. Twenty male Wistar rats (180-220 g) were included and divided into two groups. Normal saline was given intraperitoneally in the control group (n = 10). Morphine group (n = 10) received morphine intraperitoneally at a dose of 4, 8, and 10 mg/kg/day in the first, second and the third ten days of the study, respectively. Serum levels of alanine...