Saeed Samarghandian
Mashhad University of Medical Sciences
Internal medicineEndocrinologyCytotoxic T cellChemistryApoptosisImmunologySuperoxide dismutaseOxidative stressAntioxidantMalondialdehydeStreptozotocinCrocus sativusSafranalViability assayGlutathioneFlow cytometryDiabetes mellitusTraditional medicineCell growthMedicineCell cultureBiologyPharmacology
26Publications
21H-index
1,278Citations
Publications 22
Newest
#1Saeed SamarghandianH-Index: 21
#2Tahereh Farkhondeh (MUMS: Mashhad University of Medical Sciences)H-Index: 22
Last. Fariborz Samini (MUMS: Mashhad University of Medical Sciences)H-Index: 16
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Honey is one of the most appreciated and valued natural products introduced to humankind since ancient times. Honey is used not only as a nutritional product but also in health described in traditional medicine and as an alternative treatment for clinical conditions ranging from wound healing to cancer treatment. The aim of this review is to emphasize the ability of honey and its multitude in medicinal aspects. Traditionally, honey is used in the treatment of eye diseases, bronchial asthma, thro...
88 CitationsSource
#1Saeed SamarghandianH-Index: 21
#2Mohsen Azimi-Nezhad (MUMS: Mashhad University of Medical Sciences)H-Index: 23
Last. Fariborz Samini (MUMS: Mashhad University of Medical Sciences)H-Index: 16
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Abstract Restraint stress has been indicated to induce oxidative damage in tissues. Several investigations have reported that curcumin (CUR) may have a protective effect against oxidative stress. The present study was designed to investigate the protective effects of CUR on restraint stress induced oxidative stress damage in the brain, liver and kidneys. For chronic restraint stress, rats were kept in the restrainers for 1 h every day, for 21 consecutive days. The animals received systemic admin...
76 CitationsSource
#1Saeed SamarghandianH-Index: 21
#1Saeed SamarghandianH-Index: 19
Last. Tahereh Farkhondeh (MUMS: Mashhad University of Medical Sciences)H-Index: 22
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Context:Diabetes mellitus causes atherosclerosis and lipid abnormalities. Hypolipidemic and antioxidative properties of catechin (CTN) have been reported in several studies.Objective:This study assesses the possible protective effects of CTN against oxidative damage in the diabetic rats.Materials and Methods:The rats were divided into the control, untreated diabetic, and 3 CTN-treated diabetic groups (20, 40, and 80 mg/kg/d, intraperitoneal). The diabetic rats were induced by streptozotocin. Cat...
36 CitationsSource
#1Saeed SamarghandianH-Index: 21
#2Mohsen Azimi-Nezhad (MUMS: Mashhad University of Medical Sciences)H-Index: 23
Last. Tahereh Farkhondeh (MUMS: Mashhad University of Medical Sciences)H-Index: 22
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Chrysin (CH) is a natural flavonoid with pharmacological influences. The purpose of the current study was the assessment of possible protective effects of CH against oxidative damage in the serum, liver, brain, and pancreas of streptozotocin (STZ)- induced diabetic rats. In the present study, the rats were divided into the following groups of 8 animals each: control, untreated diabetic, 3 CH (20, 40, 80 mg/kg/day)-treated diabetic groups. To find out the modulations of cellular antioxidant defen...
42 CitationsSource
#1Saeed SamarghandianH-Index: 21
#2Tahereh Farkhondeh (MUMS: Mashhad University of Medical Sciences)H-Index: 22
Last. Abasalt BorjiH-Index: 14
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Restraint stress may be associated with elevated free radicals, and thus, chronic exposure to oxidative stress may cause tissue damage. Several studies have reported that carvacrol (CAR) has a protective effect against oxidative stress. The present study was designed to investigate the protective effects of CAR on restraint stress induced oxidative stress damage in the brain, liver, and kidney. For chronic restraint stress, rats were kept in the restrainers for 6 h every day, for 21 consecutive ...
60 CitationsSource
AbstractBisphenol A (BPA), an endocrine-disrupting chemical, has been considered as a possible risk factor for diabetes and its complications. However, the underlying mechanisms of BPA-induced diabetes are not clear. The present study was performed to evaluate the effects of BPA on the hyperglycemia, lipid abnormalities and oxidative stress. In this study, the mice were divided into three groups of six animals each: One group as a control (C) and two other groups which exposed to 0.5 and 2 mg/kg...
52 CitationsSource
#1Saeed SamarghandianH-Index: 21
#2Mohsen Azimi-Nezhad (MUMS: Mashhad University of Medical Sciences)H-Index: 23
Last. Fereshteh BafandehH-Index: 2
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Cadmium (Cd) is an environmental toxic metal implicated in lipid abnormalities. The present study was designed to elucidate the possible association between chronic exposure to Cd concentration and alterations in plasma lipid, lipoprotein, and oxidative stress indices in rats. Sixteen male rats were assigned to 2 groups of 8 rats each (test and control). The Cd-exposed group obtained drinking water containing cadmium chloride (CdCl2) in the concentration of 2.0 mg Cd/L in drinking water for 3 mo...
39 CitationsSource
Objectives: Honey is reported to contain various compounds such as antioxidants. Chrysin is a natural and biologically active compound extracted from honey. It possesses antioxidant properties and promotes cell death by perturbing cell cycle progression. We focused on the possible role that chrysin may act as a potential anticancer agent, and tested its biological activity and possible mechanisms in the human lung adenocarcinoma epithelial cell line. Materials & Methods: Antiproliferative effect...
41 CitationsSource
#1Saeed SamarghandianH-Index: 21
#2Mousa-Al-Reza Hadjzadeh (MUMS: Mashhad University of Medical Sciences)H-Index: 16
Last. Mohadeseh Hosseini (UT: University of Tehran)H-Index: 1
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Background We investigated the potential of galangal rhizomes to induce cytotoxic and apoptotic effects in the cultured human breast carcinoma cell line, (MCF-7) in compare with the non-malignant (MRC-5) cells.
22 CitationsSource
#1Saeed SamarghandianH-Index: 21
#2Reza Afshari (MUMS: Mashhad University of Medical Sciences)H-Index: 26
Last. Tahereh FarkhondehH-Index: 22
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In this study, biochemical changes due to long term usage of morphine in rat’s liver were assessed. Twenty male Wistar rats (180-220 g) were included and divided into two groups. Normal saline was given intraperitoneally in the control group (n = 10). Morphine group (n = 10) received morphine intraperitoneally at a dose of 4, 8, and 10 mg/kg/day in the first, second and the third ten days of the study, respectively. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST)...
31 Citations