Formulation and In vitro evaluation of Solid- Self- Emulsifying Drug Delivery System (SEDDS) of Glibenclamide

Aim of present study was to develop solid self micro emulsifying drug delivery system (S-SEDDS) with Aerosil 200 for enhancement of dissolution rate of model drug Glibenclamide (GBM). SEDDS was prepared using Capmul MCM C8 TM , Cremophor RH 40 TM , and Transcutol P TM as oil, surfactant and cosurfactant respectively. For formulation of stable SEDDS, micro emulsion region was identified by constructing pseudo ternary phase diagram containing different proportion of surfactant: co-surfactant (1:1, 2:1 and 3:1), oil and water. Prepared SEDDS was evaluated for turbidity measurement, globule size and zeta potential, viscosity determination and % transmittance. S-SEDDS was prepared by adsorption technique using Aerosil 200 as solid carrier. Prepared S-SEDDS was evaluated for flow properties, drug content, FTIR, SEM, DSC and in-vitro dissolution study. Results showed that prepared liquid SEDDS passed all evaluation tests. Globule size was found to be 142.8 nm with polydispersity index 0.396. S-SEDDS showed good flow property and drug content. From the experiment, it is clear thateven after conversion of the liquid SEDDS into the solid one there was no significant alteration in the properties of solid SEDDS. in-vitro dissolution studies showed that there was enhancement of dissolution rate of GBM as compared with that of plain drug and marketed formulation. From the results it is concluded that, Aerosil 200 can be used to develop S-SEDDS by adsorption technique to enhance dissolution rate of poorly water soluble model drug GBM.