Formulation and In vitro evaluation of Solid- Self- Emulsifying Drug Delivery System (SEDDS) of Glibenclamide

Aim of present study was to develop solid self micro emulsifying drug delivery system (S-SEDDS) with Aerosil 200 for enhancement of dissolution rate of model drug Glibenclamide (GBM). SEDDS was prepared using Capmul MCM C8 TM , Cremophor RH 40 TM , and Transcutol P TM null as oil, surfactant and cosurfactant respectively. For formulation of stable SEDDS, micro emulsion region was identified by constructing pseudo ternary phase diagram containing...