The results of surveys about antigenicity and immunotoxocity studies conducted in pharmaceutical companies in Japan.

Published on Oct 7, 1998in Journal of Toxicological Sciences1.737
N. Tsutsui2
Estimated H-index: 2
,
Naohisa Tsutsui4
Estimated H-index: 4
+ 1 AuthorsEiji Maki5
Estimated H-index: 5
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#1Akiko SudaH-Index: 2
#2Yoshinobu IwakiH-Index: 6
Last. Masaaki KimuraH-Index: 10
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The mouse popliteal lymph node assay(PLNA)has been proposed as an immunotoxicological test to predict allergenic chemicals. However, PLN response is also observed in association with non-specific activation induced by some irritants. We, therefore, examined the kinetics of the PLN cellularity indices of primary and secondary responses. Flow cytometric analysis was used to measure the proportions of T and B cells in PLN. Male ICR mice were subcutaneously injected with TNBS(an allergenic compound)...
9 CitationsSource
#1Kanade ShinkaiH-Index: 26
#1Kenkichi ShinkaiH-Index: 4
Last. Eiji MakiH-Index: 5
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In the present collaborative study, popliteal lymph node (PLN) responses to penicillin G (an allergenic chemical), D-penicillamine (an autoimmunity-inducing chemical), and barbital (a negative reference chemical) were investigated in three different mouse strains by ten pharmaceutical companies. Two inbred mouse strains (BALB/c and A/J) and one outbred strain (ICR) were subcutaneously injected with saline solutions containing penicillin G (1.25, 2.5 and 5 mg/mouse), D-penicillamine (0.5, 1 and 2...
9 CitationsSource