Evaluation of allergic potential of low molecular weight drugs by mouse popliteal lymph node assay.

Published on Oct 7, 1998in Journal of Toxicological Sciences1.737
Kenkichi Shinkai4
Estimated H-index: 4
Kanade Shinkai26
Estimated H-index: 26
+ 9 AuthorsEiji Maki5
Estimated H-index: 5
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3 Authors (M.E. Kammüller, ..., Willem Seinen)
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#1Kenkichi ShinkaiH-Index: 4
#1Kanade ShinkaiH-Index: 26
Last. Eiji MakiH-Index: 5
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In the present collaborative study, popliteal lymph node (PLN) responses to penicillin G (an allergenic chemical), D-penicillamine (an autoimmunity-inducing chemical), and barbital (a negative reference chemical) were investigated in three different mouse strains by ten pharmaceutical companies. Two inbred mouse strains (BALB/c and A/J) and one outbred strain (ICR) were subcutaneously injected with saline solutions containing penicillin G (1.25, 2.5 and 5 mg/mouse), D-penicillamine (0.5, 1 and 2...
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