Review paper
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects
Abstract
The removal of introns from mRNA precursors and its regulation by alternative splicing are key for eukaryotic gene expression and cellular function, as evidenced by the numerous pathologies induced or modified by splicing alterations. Major recent advances have been made in understanding the structures and functions of the splicing machinery, in the description and classification of physiological and pathological isoforms and in the development...
Paper Details
Title
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects
Published Date
Dec 16, 2022
Journal
Volume
24
Issue
4
Pages
251 - 269