Tumor necrosis factor alpha

Butyrate

Lymphoma

Eubacterium

Bacteria

Carcinogenesis

Biology

Fermentation

Cancer

Proinflammatory cytokine

TLR4

Immunology

Inflammation

Gastrointestinal tract

Food science

Cancer research

Genetics

Biochemistry

Cell Host & Microbe

Lu et al. identified Eubacterium rectale as a protective factor in primary intestinal lymphoma. Eubacterium rectale is a butyrate-producing bacteria that inhibits intestinal inflammation, subsequently alleviating TLR4/MyD88/NF-κB signaling in B cells. Their findings revealed a mechanism of inflammation-associated lymphomagenesis and provided clinical rationale for targeting gut microbiota involved in lymphoma progression.

Butyrate-producing Eubacterium rectale suppresses lymphomagenesis by alleviating the TNF-induced TLR4/MyD88/NF-κB axis