Cell Host & Microbe
Papers 2,552
1 page of 256 pages (2,552 results)
#1Haibo Wu (CQU: Chongqing University)H-Index: 6
#2Na Xing (FU: Freie Universität Berlin)H-Index: 3
Last. Zhenglin Zhu (CQU: Chongqing University)H-Index: 6
view all 14 authors...
Previous work found that the co-occurring mutations R203K/G204R on the SARS-CoV-2 nucleocapsid (N) protein are increasing in frequency among emerging variants of concern or interest. Through a combination of in silico analyses, this study demonstrates that R203K/G204R are adaptive, while large-scale phylogenetic analyses indicate that R203K/G204R associate with the emergence of the high-transmissibility SARS-CoV-2 lineage B.1.1.7. Competition experiments suggest that the 203K/204R variants posse...
#2Oliver F. Wirz (SU: Stanford University)H-Index: 16
Last. Naranbaatar DashdorjH-Index: 14
view all 40 authors...
Abstract: null null Different SARS-CoV-2 vaccines are approved in various countries, but few direct comparisons of the antibody responses they stimulate have been reported. We collected plasma specimens in July 2021 from 196 Mongolian participants fully vaccinated with one of four COVID-19 vaccines: Pfizer/BioNTech, AstraZeneca, Sputnik V and Sinopharm. Functional antibody testing with a panel of nine SARS-CoV-2 viral variant receptor binding domain (RBD) proteins reveal marked differences in va...
#1Paul M. Arnaboldi (NYMC: New York Medical College)H-Index: 15
#2Sukanya Narasimhan (Yale University)H-Index: 35
Lyme disease, which is caused by the spirochete Borrelia burgdorferi, is on the rise. Current treatment relies on broad-spectrum antibiotics that perturb the gut microbiome. In a recent paper in Cell, Leimer et al. demonstrate the utility of a long-forgotten antibiotic, Hygromycin A, as a spirochete-specific antibacterial that is conducive to gut health.
#1Alexandra C. U. Furch (FSU: Friedrich Schiller University Jena)H-Index: 22
#2Günter Theißen (FSU: Friedrich Schiller University Jena)H-Index: 41
Last. Matthias R. Zimmermann (FSU: Friedrich Schiller University Jena)H-Index: 2
view all 3 authors...
Phytoplasmas are pathogenic bacteria that manipulate their plant hosts in dramatic ways. In issue 20 Vol. 184 of Cell, Huang and colleagues report on a phytoplasma effector protein that brings about manifold effects by a surprising mechanism. Are resistant plants on the horizon now?
#1Nicolas G Shealy (VUMC: Vanderbilt University Medical Center)H-Index: 1
#2Mariana X. Byndloss (VUMC: Vanderbilt University Medical Center)H-Index: 22
Have you ever caught family members eating the last piece of your Halloween candy? In this issue of Cell Host & Microbe, Osbelt et al. and Eberl et al. demonstrate how commensal Enterobacteriaceae preempt pathogen carbohydrate utilization, dependent upon the composition of the surrounding gut microbial community.
#1Asma Hatoum-Aslan (UIUC: University of Illinois Urbana-Champaign)H-Index: 12
Bacteria have evolved many immune systems to combat their viral parasites (i.e., phages). In this issue of Cell Host & Microbe, Owen et al. discover a mechanism of anti-phage immunity that is mediated by a phage-encoded protein, and thus provide an example of how inter-phage conflict can promote survival of the bacterial population.
#1B. P. Girinathan (BWH: Brigham and Women's Hospital)H-Index: 4
#2Nicholas DiBenedetto (BWH: Brigham and Women's Hospital)H-Index: 5
Last. Maria Hoffman (CFSAN: Center for Food Safety and Applied Nutrition)H-Index: 1
view all 19 authors...
Summary null null Leveraging systems biology approaches, we illustrate how metabolically distinct species of Clostridia protect against or worsen Clostridioides difficile infection in mice by modulating the pathogen’s colonization, growth, and virulence to impact host survival. Gnotobiotic mice colonized with the amino acid fermenter Paraclostridium bifermentans survive infection with reduced disease severity, while mice colonized with the butyrate-producer, Clostridium sardiniense, succumb more...
#1David R. McIlwain (SU: Stanford University)H-Index: 19
#2Han Chen (SU: Stanford University)H-Index: 6
Last. Garry P. Nolan (SU: Stanford University)H-Index: 110
view all 20 authors...
Developing new influenza vaccines with improved performance and easier administration routes hinges on defining correlates of protection. Vaccine-elicited cellular correlates of protection for influenza in humans have not yet been demonstrated. A phase-2 double-blind randomized placebo and active (inactivated influenza vaccine) controlled study provides evidence that a human-adenovirus-5-based oral influenza vaccine tablet (VXA-A1.1) can protect from H1N1 virus challenge in humans. Mass cytometr...
#1Vishwas Mishra (MSK: Memorial Sloan Kettering Cancer Center)
#2Joao B. Xavier (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 49
Systems biology studies how complex dynamics emerge from many elements interacting with each other in biological systems. This definition might sound abstract, but the applications are concrete. In this issue of Cell Host & Microbe, two studies apply systems biology to study Clostridioides difficile, a major cause of hospital-acquired infections.
#1Peter W. S. Hill (Imperial College London)H-Index: 9
#2Ana L Moldoveanu (Imperial College London)H-Index: 1
Last. Sophie Helaine (Imperial College London)H-Index: 25
view all 8 authors...
Summary null null Tolerance and persistence are superficially similar phenomena by which bacteria survive bactericidal antibiotics. It is assumed that the same physiology underlies survival of individual tolerant and persistent bacteria. However, by comparing tolerance and persistence during Salmonella Typhimurium infection, we reveal that these two phenomena are underpinned by different bacterial physiologies. Multidrug-tolerant mutant Salmonella enter a near-dormant state protected from immune...
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