Internal medicine

Radiology

Neuroscience

Depression (economics)

Disease

Macroeconomics

Magnetic resonance imaging

Psychology

Economics

Stimulation

Grey matter

Treatment-resistant depression

Parkinson's disease

Hippocampus

Deep brain stimulation

Antidepressant

White matter

Brain stimulation

Medicine

Neurotherapeutics

Deep brain stimulation has been extensively studied as a therapeutic option for treatment-resistant depression (TRD). DBS across different targets is associated with on average 60% response rates in previously refractory chronically depressed patients. However, response rates vary greatly between patients and between studies and often require extensive trial-and-error optimizations of stimulation parameters. Emerging evidence from tractography imaging suggests that targeting combinations of white matter tracts, rather than specific grey matter regions, is necessary for meaningful antidepressant response to DBS.

Deep Brain Stimulation for Depression