Papers 1486
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#1Ethan M. Goldberg (UPenn: University of Pennsylvania)H-Index: 24
Genetic testing has yielded major advances in our understanding of the causes of epilepsy. Seizures remain resistant to treatment in a significant proportion of cases, particularly in severe, childhood-onset epilepsy, the patient population in which an underlying causative genetic variant is most likely to be identified. A genetic diagnosis can be explanatory as to etiology, and, in some cases, might suggest a therapeutic approach; yet, a clear path from genetic diagnosis to treatment remains un...
#1Yat Kwan Wong (HKU: University of Hong Kong)
#2Junmei Wu (HKU: University of Hong Kong)H-Index: 1
Last. Zhang-Jin Zhang (HKU: University of Hong Kong)H-Index: 33
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Depression is a common psychiatric illness affecting over 300 million people globally. Acupuncture has been reported to be a safe complementary treatment for depression. This study is aimed to investigate the efficacy and mechanism of combining acupuncture with antidepressants in treating depression compared to the sole use of antidepressants. Seventy depression patients were randomly assigned to the treatment group (n = 50) and control group (n = 20). The treatment group received acupuncture co...
#1Shannon L. Risacher (IU: Indiana University)H-Index: 54
#2Andrew J. Saykin (IU: Indiana University)H-Index: 127
#1Daniel B. Horton (RU: Rutgers University)H-Index: 14
#2Anthony T. Reder (U of C: University of Chicago)H-Index: 61
Many autoimmune diseases confer a higher risk of cancer on patients compared to the general population. A controversial factor tying autoimmune diseases to malignancy is harm from immunosuppressive treatment. Nonetheless, multiple sclerosis is different from other autoimmune diseases, and findings from other disease populations may not apply. In this issue of Neurotherapeutics, Dolladile and colleagues from France present new evidence about the risks of cancers in patients with multiple sclerosi...
#1Brenna C. McDonald (IU: Indiana University)H-Index: 31
Cancer- and treatment-related cognitive dysfunction (CRCD) is a common challenge faced by patients diagnosed with non-central nervous system (CNS) cancer. It has become increasingly recognized that multiple factors likely play a role in these symptoms, including the cancer disease process, systemic treatments (e.g., chemotherapy and endocrine therapies), and risk factors that may predispose an individual to both cancer and cognitive dysfunction. As the field has evolved, advanced neuroimaging te...
1 CitationsSource
#1Sang-Min Kim (Inha University)H-Index: 4
#2Seungjae Zhang (Konkuk University)H-Index: 2
Last. Inn-Oc Han (Inha University)H-Index: 29
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#1Bradley T Peet (UCSF: University of California, San Francisco)
#2Salvatore Spina (UCSF: University of California, San Francisco)H-Index: 36
Last. Renaud La Joie (UCSF: University of California, San Francisco)H-Index: 36
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Frontotemporal dementia encompasses a group of clinical syndromes defined pathologically by degeneration of the frontal and temporal lobes. Historically, these syndromes have been challenging to diagnose, with an average of about three years between the time of symptom onset and the initial evaluation and diagnosis. Research in the field of neuroimaging has revealed numerous biomarkers of the various frontotemporal dementia syndromes, which has provided clinicians with a method of narrowing the ...
1 CitationsSource
#1Julie Ziobro (UM: University of Michigan)H-Index: 8
#2Krista Eschbach (CU: University of Colorado Boulder)H-Index: 6
Last. Renée A. Shellhaas (UM: University of Michigan)H-Index: 32
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Neonatal seizures are a common neurologic emergency for which therapies have not significantly changed in decades. Improvements in diagnosis and pathophysiologic understanding of the distinct features of acute symptomatic seizures and neonatal-onset epilepsies present exceptional opportunities for development of precision therapies with potential to improve outcomes. Herein, we discuss the pathophysiology of neonatal seizures and review the evidence for currently available treatment. We present ...
#1Lori L. Isom (UM: University of Michigan)H-Index: 58
#2Kelly G. Knupp (Anschutz Medical Campus)H-Index: 19
Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy that is mainly associated with variants in SCN1A. While drug-resistant epilepsy is the most notable feature of this syndrome, numerous symptoms are present that have significant impact on patients' quality of life. In spite of novel, third-generation anti-seizure treatment options becoming available over the last several years, seizure freedom is often not attained and non-seizure symptoms remain. Precision medicine now ...
#1María E. Prados (Emerald Group Publishing)H-Index: 1
#2Alejandro Correa-Sáez (UCO: University of Córdoba (Spain))H-Index: 2
Last. Eduardo Muñoz (UCO: University of Córdoba (Spain))H-Index: 61
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Huntington's disease (HD) is a neurodegenerative disorder characterized by unwanted choreatic movements, behavioral and psychiatric disturbances, and dementia. The activation of the hypoxic response pathway through the pharmacological inhibition of hypoxia-inducing factor (HIF) prolyl-hydroxylases (PHDs) is a promising approach for neurodegenerative diseases, including HD. Herein, we have studied the mechanism of action of the compound Betulinic acid hydroxamate (BAH), a hypoximimetic derivative...
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