Original paper
Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection
Abstract
Two mycobacteriophages were administered intravenously to a male with treatment-refractory Mycobacterium abscessus pulmonary infection and severe cystic fibrosis lung disease. The phages were engineered to enhance their capacity to lyse M. abscessus and were selected specifically as the most effective against the subject's bacterial isolate. In the setting of compassionate use, the evidence of phage-induced lysis was observed using molecular and...
Paper Details
Title
Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection
Published Date
May 1, 2022
Journal
Volume
185
Issue
11
Pages
1860 - 1874.e12