Physics

Internal medicine

Pathology

Melanoma

Pathogenesis

Bioinformatics

Incidence (geometry)

Biology

Optics

Cancer

Oncology

Dermatology

Skin cancer

Basal cell carcinoma

Squamous cell cancer

Basal cell

Cancer research

Medicine

International Journal of Molecular Sciences

Non-melanoma skin cancers are cutaneous malignancies representing the most common form of cancer in the United States. They are comprised predominantly of basal cell carcinomas and squamous cell carcinomas (cSCC). The incidence of cSCC is increasing, resulting in substantial morbidity and ever higher treatment costs; currently in excess of one billion dollars, per annum. Here, we review research defining the molecular basis and development of cSCC that aims to provide new insights into pathogenesis and drive the development of novel, cost and morbidity saving therapies.

Molecular Mechanisms of Cutaneous Squamous Cell Carcinoma