Virology

Titer

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Neutralizing antibody

Convalescence

Coronavirus disease 2019 (COVID-19)

Immunology

Vaccination

Immunization

Infectious disease (medical specialty)

Internal medicine

Antibody response

Medicine

Pandemic

Disease

Antibody

EBioMedicine

A major challenge of the SARS-CoV-2 pandemic is to better define "protective thresholds" to guide the global response. We aimed to characterize the longitudinal dynamics of the antibody responses in naturally infected individuals in Chile and compared them to humoral responses induced after immunization with CoronaVac-based on an inactivated whole virus -or the BNT162b2- based on mRNA-vaccines. We also contrasted them with the respective effectiveness and efficacy data available for both vaccines.

Induction of SARS-CoV-2 neutralizing antibodies by CoronaVac and BNT162b2 vaccines in naïve and previously infected individuals