Pathology

Enzyme

Virus

Disease

Coronavirus disease 2019 (COVID-19)

Infectious disease (medical specialty)

Biology

Infectivity

Outbreak

Virology

TMPRSS2

Betacoronavirus

Furin

Coronavirus

2019-20 coronavirus outbreak

Computational biology

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Genetics

Biochemistry

Medicine

Journal of Virology

SARS-CoV-2, the etiological agent of COVID-19, has so far resulted in &gt;6.1 million deaths worldwide. The spike protein (S) of the virus directs infection of the lungs and other tissues by binding the angiotensin-converting enzyme 2 (ACE2) receptor.

Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity