Gene

Biology

Farnesyl pyrophosphate

Endocrinology

Quail

Biochemistry

Quorum sensing

Dimorphic fungus

Hypha

Candida albicans

Mevalonate pathway

Biosynthesis

Microbiology

Enzyme

Trehalose

Farnesol

Morphogenesis

Virulence

Yeast

Animals

Candida albicans was the first eukaryotic microorganism to exhibit quorum-sensing through the secretion of the sesquiterpene E, farnesol. This molecule is generated by dephosphorylation of farnesyl pyrophosphate in the mevalonate biosynthetic pathway in mammalian and yeast cells. Exogenous farnesol inhibits yeast-to-hyphal formation in a concentration- and time-dependent manner at the earliest stage of hyphal development. Much research has been devoted to studying the role of farnesol as an inhibitor of hyphal morphogenesis; however, little research has been published regarding the in vivo impacts of farnesol on fungal virulence and the development of Candida infection. While other studies have examined the impact of multiple doses of farnesol in addition to antimycotics, we hypothesize that C. albicans treated with a single dose of this quorum-sensing molecule could reduce fungal virulence in a quail model.

Reduction in Pathogenicity in Yeast-like Fungi by Farnesol in Quail Model