Anatomically distinct fibroblast subsets determine skin autoimmune patterns

The skin serves as a physical barrier and an immunological interface that protects the body from the external environment1–3. Aberrant activation of immune cells can induce common skin autoimmune diseases such as vitiligo, which are often characterized by bilateral symmetric lesions in certain anatomic regions of the body4–6. Understanding what orchestrates the activities of cutaneous immune cells at an organ level is necessary for the treatment...