Internal medicine

Adverse effect

Immunogenicity

Streptococcus pneumoniae

Mathematics

Antibiotics

Biology

Microbiology

Mathematical analysis

Antibody

Conjugate

Randomized controlled trial

Immunology

Pneumococcal conjugate vaccine

Tolerability

Clinical trial

Medicine

Clinical Infectious Diseases

Pneumococcal conjugate vaccines (PCVs) have significantly reduced pneumococcal disease, but disease from non-PCV serotypes remains. The safety, tolerability, and immunogenicity of a 20-valent PCV (PCV20) were evaluated.

Pivotal Phase 3 Randomized Clinical Trial of the Safety, Tolerability, and Immunogenicity of 20-Valent Pneumococcal Conjugate Vaccine in Adults Aged ≥18 Years