Original paper
Ig Enhancers Increase RNA Polymerase II Stalling at Somatic Hypermutation Target Sequences
Abstract
Somatic hypermutation (SHM) drives the genetic diversity of Ig genes in activated B cells and supports the generation of Abs with increased affinity for Ag. SHM is targeted to Ig genes by their enhancers (diversification activators [DIVACs]), but how the enhancers mediate this activity is unknown. We show using chicken DT40 B cells that highly active DIVACs increase the phosphorylation of RNA polymerase II (Pol II) and Pol II occupancy in the...
Paper Details
Title
Ig Enhancers Increase RNA Polymerase II Stalling at Somatic Hypermutation Target Sequences
Published Date
Jan 1, 2022
Journal
Volume
208
Issue
1
Pages
143 - 154
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Notes
History