Journal of Immunology
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#1Yoojin Choi (U of T: University of Toronto)H-Index: 1
#2Sarah Grech (U of T: University of Toronto)H-Index: 1
Last. Rupert KaulH-Index: 70
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Although antiretroviral treatment (ART) suppresses HIV RNA in blood and prevents transmission, low-level anorectal HIV RNA shedding persists in some ART-treated men who have sex with men. We collected anorectal biopsies and swabs from 55 men who have sex with men on effective ART, hypothesizing that anorectal shedding would be linked to microbiota-driven mucosal T cell activation. Lymphocytes were assessed by flow cytometry, soluble immune factors by multiplex immunoassay, neutrophils and epithe...
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#1Gil Diamant (TAU: Tel Aviv University)H-Index: 1
#2Hadar Simchony Goldman (TAU: Tel Aviv University)
Last. Rachel Grossman (TAU: Tel Aviv University)H-Index: 21
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Tumor-treating fields (TTFields) are a localized, antitumoral therapy using alternating electric fields, which impair cell proliferation. Combining TTFields with tumor immunotherapy constitutes a rational approach; however, it is currently unknown whether TTFields' locoregional effects are compatible with T cell functionality. Healthy donor PBMCs and viably dissociated human glioblastoma samples were cultured under either standard or TTFields conditions. Select pivotal T cell functions were meas...
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#1Saskia D. van Asten (UvA: University of Amsterdam)H-Index: 2
#2Peter-Paul A. Unger (UvA: University of Amsterdam)H-Index: 4
Last. Robbert M. Spaapen (UvA: University of Amsterdam)H-Index: 20
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Differentiation of Ag-specific B cells into class-switched, high-affinity, Ab-secreting cells provides protection against invading pathogens but is undesired when Abs target self-tissues in autoimmunity, beneficial non-self-blood transfusion products, or therapeutic proteins. Essential T cell factors have been uncovered that regulate T cell-dependent B cell differentiation. We performed a screen using a secreted protein library to identify novel factors that promote this process and may be used ...
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#1Vittoria Massafra (Hoffmann-La Roche)
#2Sofia Tundo (Hoffmann-La Roche)
Last. Andrea Romagnani (Hoffmann-La Roche)
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The availability of Ags on the surface of tumor cells is crucial for the efficacy of cancer immunotherapeutic approaches using large molecules, such as T cell bispecific Abs (TCBs). Tumor Ags are processed through intracellular proteasomal protein degradation and are displayed as peptides on MHC class I (MHC I). Ag recognition through TCRs on the surface of CD8+ T cells can elicit a tumor-selective immune response. In this article, we show that proteolysis-targeting chimeras (PROTACs) that targe...
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#1David Calianese (RU: Rutgers University)H-Index: 6
#2Tamara Kreiss (RU: Rutgers University)
Last. Dabbu Kumar Jaijyan (RU: Rutgers University)H-Index: 5
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Phosphatidylserine (PS)-targeting monoclonal Abs (mAbs) that directly target PS and target PS via β2-gp1 (β2GP1) have been in preclinical and clinical development for over 10 y for the treatment of infectious diseases and cancer. Although the intended targets of PS-binding mAbs have traditionally included pathogens as well as stressed tumor cells and its associated vasculature in oncology, the effects of PS-targeting mAbs on activated immune cells, notably T cells, which externalize PS upon Ag s...
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#1Jiejie Sun (Dalian Ocean University)H-Index: 5
#2Lei Gao (Dalian Ocean University)H-Index: 1
Last. Linsheng Song (Dalian Ocean University)H-Index: 62
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C-type lectins are a family of pattern recognition receptors that recognize microbial components and subsequently activate the signaling cascade to induce the production of proinflammatory cytokines. In the current study, the homologs of ERK (named as CgERK) and GSK3β (named as CgGSK3β) and a novel C-type lectin with a transmembrane domain (named as CgCLec-TM1) were identified from oyster Crassostrea gigasCgCLec-TM1 was able to bind Escherichia coli and Vibrio splendidus through its carbohydrate...
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#1Rashmi Tippalagama (La Jolla Institute for Allergy and Immunology)H-Index: 1
#2Akul Singhania (La Jolla Institute for Allergy and Immunology)
Last. Dhammika VidanagamaH-Index: 4
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Upon Ag encounter, T cells can rapidly divide and form an effector population, which plays an important role in fighting acute infections. In humans, little is known about the molecular markers that distinguish such effector cells from other T cell populations. To address this, we investigated the molecular profile of T cells present in individuals with active tuberculosis (ATB), where we expect Ag encounter and expansion of effector cells to occur at higher frequency in contrast to Mycobacteriu...
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#1Dan-Dan Chen (CAS: Chinese Academy of Sciences)H-Index: 14
#2Jing-Yu Jiang (CAS: Chinese Academy of Sciences)H-Index: 1
Last. Shun Li (CAS: Chinese Academy of Sciences)H-Index: 13
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Fish IFN regulatory factor 3 (IRF3) is a crucial transcription factor in the IFN activation signaling pathway, which leads to IFN production and a positive cycle. Unrestricted IFN expression results in hyperimmune responses and therefore, IFN must be tightly regulated. In the current study, we found that zebrafish Ub-activating enzyme (Uba1) negatively regulated IRF3 via the K-48 ubiquitin proteasome degradation of IRF3. First, ifn expression stimulated by spring viraemia of carp virus infection...
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#1Jin Na Shin (BCM: Baylor College of Medicine)H-Index: 3
#2Lang Rao (UCI: University of California, Irvine)
Last. N Tony Eissa (UCI: University of California, Irvine)H-Index: 1
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Inflammation contributes to the pathogenesis and morbidity of wide spectrum of human diseases. The inflammatory response must be actively controlled to prevent bystander damage to tissues. Yet, the mechanisms controlling excessive inflammatory responses are poorly understood. NLRP3 inflammasome plays an important role in innate immune response to cellular infection or stress. Its activation must be tightly regulated because uncontrolled inflammasome activation is associated with a number of huma...
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Molecular biology
Immunology
T cell
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Immune system
Cell biology