Journal of Immunology
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#1Alina Tarsalainen (University of Turku)
#2Yaakov Maman (BIU: Bar-Ilan University)H-Index: 13
Last. Jukka Alinikula (University of Turku)H-Index: 9
view all 11 authors...
Somatic hypermutation (SHM) drives the genetic diversity of Ig genes in activated B cells and supports the generation of Abs with increased affinity for Ag. SHM is targeted to Ig genes by their enhancers (diversification activators [DIVACs]), but how the enhancers mediate this activity is unknown. We show using chicken DT40 B cells that highly active DIVACs increase the phosphorylation of RNA polymerase II (Pol II) and Pol II occupancy in the mutating gene with little or no accompanying increase...
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#1Fatemeh Fattahi (UM: University of Michigan–Ann Arbor)H-Index: 17
#2J. Ellis (UM: University of Michigan–Ann Arbor)H-Index: 1
Last. Ulus Atasoy (UM: University of Michigan–Ann Arbor)H-Index: 2
view all 8 authors...
RNA-binding protein HuR (ELAVL1) is a master regulator of gene expression in human pathophysiology. Its dysregulation plays an important role in many diseases. We hypothesized that HuR plays an important role in Th2 inflammation in asthma in both mouse and human. To address this, we used a model of airway inflammation in a T cell-specific knockout mouse model, distal lck-Cre HuRfl/fl, as well as small molecule inhibitors in human peripheral blood-derived CD4+ T cells. Peripheral CD4+ T cells wer...
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#1Jonathan D. SilkH-Index: 17
#2Rachel AbbottH-Index: 14
Last. Joanna E. BrewerH-Index: 9
view all 27 authors...
Adoptive T cell therapy with T cells expressing affinity-enhanced TCRs has shown promising results in phase 1/2 clinical trials for solid and hematological tumors. However, depth and durability of responses to adoptive T cell therapy can suffer from an inhibitory tumor microenvironment. A common immune-suppressive agent is TGF-β, which is secreted by tumor cells and cells recruited to the tumor. We investigated whether human T cells could be engineered to be resistant to inhibition by TGF-β. Tru...
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#1Christopher Chiu (University of Melbourne)H-Index: 24
#2Judy J. Chang (University of Melbourne)H-Index: 4
Last. Sharon R Lewin (RMH: Royal Melbourne Hospital)H-Index: 66
view all 14 authors...
In people with HIV (PWH) on antiretroviral therapy (ART), immune dysfunction persists, including elevated expression of immune checkpoint (IC) proteins on total and HIV-specific T cells. Reversing immune exhaustion is one strategy to enhance the elimination of HIV-infected cells that persist in PWH on ART. We aimed to evaluate whether blocking CTL-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1), T cell Ig domain and mucin domain 3 (TIM-3), T cell Ig and ITIM domain (TIGIT) ...
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#1Xaria X. Li (UQ: University of Queensland)H-Index: 8
#2Declan M. Gorman (UQ: University of Queensland)H-Index: 1
Last. Trent M. Woodruff (UQ: University of Queensland)H-Index: 46
view all 5 authors...
The anaphylatoxin C5a is core effector of complement activation. C5a exerts potent proinflammatory and immunomodulatory actions through interacting with its C5a receptors, C5aR1 and C5aR2, modulating multiple signaling and functional activities of immune cells. Native C5a contains a large N-linked glycosylation site at Asn64, which accounts for up to 25% of its m.w. To date, the vast majority of published studies examining C5a are performed using Escherichia coli-generated recombinant C5a, which...
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#1Pushpa Tandon (NIH: National Institutes of Health)H-Index: 10
#2Natalie Abrams (NIH: National Institutes of Health)H-Index: 5
Last. Christina H. Liu (NIH: National Institutes of Health)H-Index: 17
view all 15 authors...
Metabolism and inflammation have been viewed as two separate processes with distinct but critical functions for our survival: metabolism regulates the utilization of nutrients, and inflammation is responsible for defense and repair. Both respond to an organism's stressors to restore homeostasis. The interplay between metabolic status and immune response (immunometabolism) plays an important role in maintaining health or promoting disease development. Understanding these interactions is critical ...
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#1Karen B. Whittington (VHA: Veterans Health Administration)H-Index: 11
#2Amanda Prislovsky (VHA: Veterans Health Administration)H-Index: 5
Last. Edward F. Rosloniec (VHA: Veterans Health Administration)H-Index: 25
view all 6 authors...
Ag-specific immunotherapy is a long-term goal for the treatment of autoimmune diseases; however developing a means of therapeutically targeting autoimmune T cells in an Ag-specific manner has been difficult. Through the engineering of an HLA-DR1 chimeric Ag receptor (CAR), we have produced CD8+ CAR T cells that target CD4+ T cells in an Ag-specific manner and tested their ability to inhibit the development of autoimmune arthritis in a mouse model. The DR1 CAR molecule was engineered to contain C...
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#1Wu B (UCLA: University of California, Los Angeles)H-Index: 1
#2Arunachalam Ramaiah (UCI: University of California, Irvine)H-Index: 7
Last. Sonal Srikanth (UCLA: University of California, Los Angeles)H-Index: 26
view all 6 authors...
ORAI1 and stromal interaction molecule 1 (STIM1) are the critical mediators of store-operated Ca2+ entry by acting as the pore subunit and an endoplasmic reticulum-resident signaling molecule, respectively. In addition to Ca2+ signaling, STIM1 is also involved in regulation of the type I IFN (IFN-I) response. To examine their potential role in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, we generated ORAI1 and STIM1 knockout human HEK293-angiotensin-converting enzyme 2...
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#1Jessica L. Ray (UM: University of Montana)H-Index: 3
#2Pamela Shaw (UM: University of Montana)H-Index: 1
Last. Andrij Holian (UM: University of Montana)H-Index: 49
view all 5 authors...
The majority of lung diseases occur with a sex bias in terms of prevalence and/or severity. Previous studies demonstrated that, compared with males, female mice develop greater eosinophilic inflammation in the airways after multiwalled carbon nanotube (MWCNT) exposure. However, the mechanism by which this sex bias occurs is unknown. Two immune cells that could account for the sex bias are type II innate lymphoid cells (ILC2s) and alveolar macrophages (AMs). In order to determine which immune cel...
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#1Sonwabile Dzanibe (UCT: University of Cape Town)H-Index: 2
#2Katie Lennard (UCT: University of Cape Town)H-Index: 8
Last. Clive M. Gray (UCT: University of Cape Town)H-Index: 22
view all 9 authors...
Few studies have investigated immune cell ontogeny throughout the neonatal and early pediatric period, when there is often increased vulnerability to infections. In this study, we evaluated the dynamics of two critical T cell populations, T regulatory (Treg) cells and Th17 cells, over the first 36 wk of human life. First, we observed distinct CD4+ T cells phenotypes between cord blood and peripheral blood, collected within 12 h of birth, showing that cord blood is not a surrogate for newborn blo...
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