Journal of Immunology
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#1Xiaohuan Chen (Southern Medical University)H-Index: 2
#2Yun Liu (University of Toledo Medical Center)H-Index: 1
Last. Zhixing K. Pan (University of Toledo Medical Center)H-Index: 27
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Dominant infiltration of neutrophils is a hallmark of many inflammatory diseases, especially in septic shock. IL-1β as one of the most early released proinflammatory cytokine in neutrophil, plays a pivotal role in the progress of sepsis. In this study, we built a high-throughput-compatible drug screen assay platform based on our newly constructed reporter C57BL/6 mice, pIL1-DsRed, expressing the DsRed gene under the control of the IL-1β promoter. After screening 1200 U.S. Food and Drug Administr...
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#1Rocío SimónH-Index: 4
Last. Carolina TafallaH-Index: 32
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TNF superfamily (TNFSF) members, such as BAFF and a proliferation-inducing ligand (APRIL), emerged in vertebrates as key regulators of B cell homeostasis and activation. Many cartilaginous and teleost fish contain an additional gene, designated as BAFF- and APRIL-like molecule (BALM), of unknown function and lost in tetrapods. In this study, we have performed a wide characterization of the functions of BALM on naive B cells for the first time, to our knowledge, in teleosts using rainbow trout (O...
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#1Suzanne Salti (UdeM: Université de Montréal)H-Index: 4
#2Loubna Al-Zoobi (UdeM: Université de Montréal)H-Index: 4
Last. Walid Mourad (UdeM: Université de Montréal)H-Index: 31
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In addition to the membrane-bound form, CD154 also exists as a soluble molecule originating from an intracellular and membrane cleavage. We have previously shown that CD154 cleavage from T cell surface is mediated by CD40 and involves the action of ADAM10/ADAM17 enzymes. In the aim of defining the importance of CD154 maintained on cell surface, we generated a CD154 mutated at the cleavage site. Our data show that the double mutation of E112 and M113 residues of CD154 abolishes its spontaneous re...
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#1Isabelle Allaeys (Laval University)H-Index: 12
#2Flavia Ribeiro de Vargas (Laval University)
Last. Patrice E. Poubelle (Laval University)H-Index: 35
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The concept of plasticity of neutrophils is highlighted by studies showing their ability to transdifferentiate into APCs. In this regard, transdifferentiated neutrophils were found at inflammatory sites of autoimmune arthritis (AIA). Exposure of neutrophils to inflammatory stimuli prolongs their survival, thereby favoring the acquisition of pathophysiologically relevant phenotypes and functions. By using microarrays, quantitative RT-PCR, and ELISAs, we showed that long-lived (LL) neutrophils obt...
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#1Wenliang Pan (Harvard University)
#1Wenliang Pan (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 17
Last. George C. Tsokos (Harvard University)H-Index: 75
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Protein phosphatase 2A (PP2A) composed of a scaffold subunit, a catalytic subunit, and multiple regulatory subunits is a ubiquitously expressed serine/threonine phosphatase. We have previously shown that the PP2A catalytic subunit is increased in T cells from patients with systemic lupus erythematosus and promotes IL-17 production by enhancing the activity of Rho-associated kinase (ROCK) in T cells. However, the molecular mechanism whereby PP2A regulates ROCK activity is unknown. In this study, ...
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#1Neha Sangewar (KSU: Kansas State University)H-Index: 4
#2Suryakant D. Waghela (A&M: Texas A&M University)H-Index: 17
Last. Waithaka Mwangi (KSU: Kansas State University)H-Index: 19
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Studies of immune responses elicited by bovine viral diarrhea virus (BVDV) vaccines have primarily focused on the characterization of neutralizing B cell and CD4 + T cell epitopes. Despite the availability of commercial vaccines for decades, BVDV prevalence in cattle has remained largely unaffected. There is limited knowledge regarding the role of BVDV-specific CD8+ T cells in immune protection, and indirect evidence suggests that they play a crucial role during BVDV infection. In this study, th...
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#1Heather ParkerH-Index: 9
#2Nina DickerhofH-Index: 12
Last. Mark B. HamptonH-Index: 48
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Neutrophils are often the major leukocyte at sites of mycobacterial infection, yet little is known about their ability to kill mycobacteria. In this study we have investigated whether the potent antibacterial oxidant hypochlorous acid (HOCl) contributes to killing of Mycobacterium smegmatis when this bacterium is phagocytosed by human neutrophils. We found that M. smegmatis were ingested by neutrophils into intracellular phagosomes but were killed slowly. We measured a t 1/2 of 30 min for the su...
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#1Beatriz E. Bolívar (BCM: Baylor College of Medicine)H-Index: 1
#2Alexandra N. Brown-Suedel (BCM: Baylor College of Medicine)
Last. Lisa Bouchier-Hayes (BCM: Baylor College of Medicine)H-Index: 25
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Excessive release of heme from RBCs is a key pathophysiological feature of several disease states, including bacterial sepsis, malaria, and sickle cell disease. This hemolysis results in an increased level of free heme that has been implicated in the inflammatory activation of monocytes, macrophages, and the endothelium. In this study, we show that extracellular heme engages the human inflammatory caspases, caspase-1, caspase-4, and caspase-5, resulting in the release of IL-1β. Heme-induced IL-1...
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#1Sylvia Torres-Odio (A&M: Texas A&M University)H-Index: 3
#2Yuanjiu Lei (A&M: Texas A&M University)H-Index: 3
Last. A. Phillip West (A&M: Texas A&M University)H-Index: 18
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Caseinolytic mitochondrial matrix peptidase proteolytic subunit (CLPP) is a serine protease that degrades damaged or misfolded mitochondrial proteins. CLPP-null mice exhibit growth retardation, deafness, and sterility, resembling human Perrault syndrome, but also display immune system alterations. However, the molecular mechanisms and signaling pathways underlying immunological changes in CLPP-null mice remain unclear. In this study, we report the steady-state activation of type I IFN signaling ...
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Molecular biology
Immunology
T cell
Biology
Immune system
Cell biology