Journal of Immunology
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#1Luke B. Roberts ('KCL': King's College London)H-Index: 5
#2Geraldine M. Jowett ('KCL': King's College London)H-Index: 2
Last. Graham M. Lord ('KCL': King's College London)H-Index: 50
view all 19 authors...
Innate lymphoid cells are central to the regulation of immunity at mucosal barrier sites, with group 2 innate lymphoid cells (ILC2s) being particularly important in type 2 immunity. In this study, we demonstrate that microRNA(miR)-142 plays a critical, cell-intrinsic role in the homeostasis and function of ILC2s. Mice deficient for miR-142 expression demonstrate an ILC2 progenitor-biased development in the bone marrow, and along with peripheral ILC2s at mucosal sites, these cells display a great...
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#1Harshada Ketkar (University of Connecticut Health Center)
#2Andrew G. Harrison (University of Connecticut Health Center)H-Index: 2
Last. Penghua Wang (University of Connecticut Health Center)H-Index: 33
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Type I/III IFNs induce expression of hundreds of IFN-stimulated genes through the JAK/STAT pathway to combat viral infections. Although JAK/STAT signaling is seemingly straightforward, it is nevertheless subjected to complex cellular regulation. In this study, we show that an ubiquitination regulatory X (UBX) domain-containing protein, UBXN6, positively regulates JAK-STAT1/2 signaling. Overexpression of UBXN6 enhanced type I/III IFNs-induced expression of IFN-stimulated genes, whereas deletion o...
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#1Sreya Das (IITB: Indian Institute of Technology Bombay)H-Index: 2
#2Vishakha Surve (IITB: Indian Institute of Technology Bombay)H-Index: 1
Last. Rahul Purwar (IITB: Indian Institute of Technology Bombay)H-Index: 11
view all 9 authors...
IL-9 is produced by Th9 cells and is classically known as a growth-promoting cytokine. Although protumorigenic functions of IL-9 are described in T cell lymphoma, recently, we and others have reported anti-tumor activities of IL-9 in melanoma mediated by mast cells and CD8+ T cells. However, involvement of IL-9 in invasive breast and cervical cancer remains unexplored. In this study, we demonstrate IL-9-dependent inhibition of metastasis of both human breast (MDA-MB-231 and MCF-7) and cervical (...
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#1Adam M Sandor (UNC: University of North Carolina at Chapel Hill)
#2Michael S Sturdivant (UNC: University of North Carolina at Chapel Hill)
Last. Jenny P.-Y. Ting (UNC: University of North Carolina at Chapel Hill)H-Index: 87
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Seasonal influenza and the current COVID-19 pandemic represent looming global health challenges. Efficacious and safe vaccines remain the frontline tools for mitigating both influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced diseases. This review will discuss the existing strategies for influenza vaccines and how these strategies have informed SARS-CoV-2 vaccines. It will also discuss new vaccine platforms and potential challenges for both viruses.
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#1Tobias Strid (Linköping University)H-Index: 11
#2Kazuki Okuyama (Linköping University)H-Index: 5
Last. Mikael Sigvardsson (Linköping University)H-Index: 48
view all 13 authors...
B lymphocyte development is dependent on the interplay between the chromatin landscape and lineage-specific transcription factors. It has been suggested that B lineage commitment is associated with major changes in the nuclear chromatin environment, proposing a critical role for lineage-specific transcription factors in the formation of the epigenetic landscape. In this report, we have used chromosome conformation capture in combination with assay for transposase-accessible chromatin sequencing ...
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#1Wentao Chen (NIHR: National Institute for Health Research)
#2Jian Luo (NIHR: National Institute for Health Research)
Last. Luzheng Xue (NIHR: National Institute for Health Research)H-Index: 27
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Human type 2 cytotoxic T (Tc2) cells are enriched in severe eosinophilic asthma and can contribute to airway eosinophilia. PGD2 and its receptor PGD2 receptor 2 (DP2) play important roles in Tc2 cell activation, including migration, cytokine production, and survival. In this study, we revealed novel, to our knowledge, functions of the PGD2/DP2 axis in Tc2 cells to induce tissue-remodeling effects and IgE-independent PGD2 autocrine production. PGD2 upregulated the expression of tissue-remodeling ...
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#1Jose D. Pagan (Harvard University)H-Index: 4
#2Hera Vlamakis (Broad Institute)H-Index: 45
Last. Robert M. Anthony (Harvard University)H-Index: 30
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Generation of high-affinity IgG is essential for defense against infections and cancer, which is the intended consequence of many vaccines, but can cause autoimmune and inflammatory diseases when inappropriately directed against self. The interplay of T follicular helper (TFH) cells and T follicular regulatory (TFR) cells is critical for the production of high-affinity IgG of a specific subclass. In this study, we sought to improve Ag-specific IgG responses with two interventions intended to tra...
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#1Wei Cao (WHU: Wuhan University)H-Index: 1
#2Yifei Guo (WHU: Wuhan University)H-Index: 1
Last. Ying Zhu (WHU: Wuhan University)H-Index: 34
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The antiviral innate immune responses are crucial steps during host defense and must be strictly regulated, but the molecular mechanisms of control remain unclear. In this study, we report increased expression of human ATPase Na+/K+ transporting subunit β 1(ATP1B1) after DNA and RNA virus infections. We found that the expression of ATP1B1 can inhibit viral replication and increase the levels of IFNs, IFN-stimulated genes, and inflammatory cytokines. Knockdown of ATP1B1 by specific short hairpin ...
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#1Paulina Chalan (Johns Hopkins University)H-Index: 2
#2Nithya Thomas (Johns Hopkins University)
Last. Patrizio Caturegli (Johns Hopkins University)H-Index: 32
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Autoimmune hypophysitis is classified as primary if its origin is idiopathic and secondary if it develops as a consequence of treatment with immune checkpoint inhibitors. Expanding use of immunotherapy has been paralleled by the increasing hypophysitis prevalence. However, understanding of the immune responses driving the disease remains limited. Using a mouse model of primary hypophysitis, we have identified CD4+ T lymphocytes to be the main pituitary-infiltrating immune cell population. Functi...
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#1Qian Wen (Southern Medical University)H-Index: 14
#2Yanfen Li (Southern Medical University)H-Index: 2
Last. Li Ma (Southern Medical University)H-Index: 17
view all 16 authors...
Mycobacterium tuberculosis, the pathogen that causes tuberculosis, exhibits complex host-pathogen interactions. Pattern recognition receptors and their downstream signaling pathways play crucial roles in determining the outcome of infection. In particular, the scaffold protein β-arrestin 2 mediates downstream signaling of G protein-coupled receptors. However, the role of β-arrestin 2 in conferring immunity against M. tuberculosis has not yet been explored. We found that β-arrestin 2 was upregula...
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