Optimized 3D-printed template design for production of silicone skin chambers

Silicone chambers implanted onto the dorsal skin of immunodeficient mice have been widely used in studies of hair reconstitution assay [1,2], skin regeneration [3], and tumor formation [4,5]. Recent use of humanized animal models facilitates assessment of skin-associated cellular physiology [6,7]. Researchers have mainly been using commercially-available chambers; however, these are generally globally unavailable through sales agents. When...