Journal of Dermatological Science
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8296
Papers 8290
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#1Tetsuya Magara (Nagoya City University)H-Index: 2
#2Motoki Nakamura (Nagoya City University)H-Index: 9
Last. Akimichi Morita (Nagoya City University)H-Index: 50
view all 8 authors...
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#1Ikuko Ueda-Hayakawa (Kanazawa University)H-Index: 9
#2Manabu Fujimoto (Kanazawa University)H-Index: 83
Last. Masataka Kuwana (Nippon Medical School)H-Index: 78
view all 11 authors...
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Abstract With recent advances in genetic engineering technology, gene therapy is now being considered as a treatment not only for congenital diseases but also acquired diseases, such as cancer. Gene therapeutic agents for hereditary immune disorders, haemophilia, retinal diseases, neurodegenerative diseases, and lymphoma have been approved in the United States and Europe. In the field of dermatology, clinical trials of gene therapy have been conducted, because the skin is an easily accessible or...
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#1Chi Hyun Park (SNU: Seoul National University)H-Index: 12
#1Chi Hyun Park (Seoul National University Hospital)H-Index: 1
Last. Jin Ho ChungH-Index: 57
view all 7 authors...
Abstract Background Melanin plays important roles in determining human skin color and protecting human skin cells against harmful ultraviolet light. However, abnormal hyperpigmentation in some areas of the skin may become aesthetically unpleasing, resulting in the need for effective agents or methods to regulate undesirable hyperpigmentation. Objective We investigated the effect of harmine, a natural harmala alkaloid belonging to the beta-carboline family, on melanin synthesis and further explor...
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#1Xiangzhi Li (Southern Medical University)H-Index: 1
#2Chen Zhang (Southern Medical University)H-Index: 1
Last. Meijuan Zhou (Southern Medical University)H-Index: 8
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BACKGROUND Aberrant expression of Armadillo repeat containing 8 (ARMC8) plays crucial roles in tumor growth and metastasis of various cancers. The specific role of ARMC8 in cutaneous squamous cell carcinoma (cSCC) is yet to be elucidated. OBJECTIVE The present study aimed to investigate the molecular mechanisms of ARMC8 and epithelial-mesenchymal transition (EMT) in cSCC development and provide translational insights for future therapeutics. METHODS cSCC tumor specimens were used to determine th...
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#1Sabine Altrichter (Charité)H-Index: 23
#2Y. Wang (Charité)H-Index: 1
Last. Marcus Maurer (Charité)H-Index: 81
view all 6 authors...
Abstract Background Cholinergic urticaria (CholU) is characterized by the occurrence of itchy wheals induced by sweating. Intradermal injections of acetylcholine (ACh) have been proposed to help with diagnosing CholU and subgrouping of patients, but controlled studies are largely missing. Objective To compare the rates of positive ACh test results in well characterized CholU patients and controls and to identify clinical features of CholU linked to ACh reactivity. Methods Acetylcholine was injec...
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BACKGROUND Alopecia areata (AA) is an autoimmune disease resulting in non-scarring hair loss. Animal models are useful means to identify candidates for therapeutic agents. The C3H/HeJ mouse AA model induced via transferring cultured lymphoid cells isolated from AA-affected mice is widely used for AA research. However, this conventional method requires the continuous breeding of AA mice. OBJECTIVE We aimed to establish a new method to generate AA model using the transfer of cryopreserved cells, w...
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#1Thomas A. Luger (WWU: University of Münster)H-Index: 95
#2Masayuki Amagai (Keio: Keio University)H-Index: 91
Last. Matthias Schmuth (Innsbruck Medical University)H-Index: 52
view all 13 authors...
Abstract Atopic dermatitis (AD) is a chronic, inflammatory skin disorder characterized by eczematous and pruritic skin lesions. In recent decades, the prevalence of AD has increased worldwide, most notably in developing countries. The enormous progress in our understanding of the complex composition and functions of the epidermal barrier allows for a deeper appreciation of the active role that the skin barrier plays in the initiation and maintenance of skin inflammation. The epidermis forms a ph...
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#1Misaki Kinoshita-Ise (U of T: University of Toronto)H-Index: 3
#2Manabu Ohyama (Kyorin University)H-Index: 27
Last. Neil H. Shear (U of T: University of Toronto)H-Index: 77
view all 8 authors...
Abstract Background Ultra high-frequency ultrasound (uHFUS) is a recently developed diagnostic technology. Despite its potential usefulness, no study has assessed its advantage in diagnosis and evaluation of hair disorders in comparison with other diagnostic methods. Objectives To assess the practicability of uHFUS in diagnosing hair disorders and propose a diagnostic methodology. Methods Ultrasonographic images of scalp and forehead from patients with hair disorders (n = 103) and healthy contro...
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#1Akira Kaneko (Kumamoto University)
#2Hisashi Kanemaru (Kumamoto University)H-Index: 8
Last. Hironobu Ihn (Kumamoto University)H-Index: 69
view all 15 authors...
Abstract Background The development of BRAF/MEK inhibitors in patients with metastatic melanoma harboringBRAF mutations has garnered attention for liquid biopsy to detect BRAF mutations in cell-free DNA (cfDNA) using droplet digital PCR (ddPCR) or next-generation sequencing methods. Objective To investigate gene mutations in tumor DNA and cfDNA collected from 43 melanoma patients and evaluate their potential as biomarkers. Methods ddPCR and CAncer Personalized Profiling by deep Sequencing (CAPP-...
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