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Original paper

An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy

Volume: 219, Issue: 1
Published: Nov 23, 2021
Abstract
We describe the discovery of an agonist of the nuclear receptor NR2F1 that specifically activates dormancy programs in malignant cells. The agonist led to a self-regulated increase in NR2F1 mRNA and protein and downstream transcription of a novel dormancy program. This program led to growth arrest of an HNSCC PDX line, human cell lines, and patient-derived organoids in 3D cultures and in vivo. This effect was lost when NR2F1 was knocked out by...
Paper Details
Title
An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy
Published Date
Nov 23, 2021
Volume
219
Issue
1
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