An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy
Abstract
We describe the discovery of an agonist of the nuclear receptor NR2F1 that specifically activates dormancy programs in malignant cells. The agonist led to a self-regulated increase in NR2F1 mRNA and protein and downstream transcription of a novel dormancy program. This program led to growth arrest of an HNSCC PDX line, human cell lines, and patient-derived organoids in 3D cultures and in vivo. This effect was lost when NR2F1 was knocked out by...
Paper Details
Title
An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy
Published Date
Nov 23, 2021
Volume
219
Issue
1
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