Original paper
Endoplasmic reticulum stress-induced release and binding of calreticulin from human ovarian cancer cells
Abstract
Background Calreticulin (CRT) is an endoplasmic reticulum (ER) chaperone, but can appear surface bound on cancers cells, including ovarian cancers (OC). We investigated at what stage of cell viability, CRT appeared associated with surface of human OC cells. CRT on pre-apoptotic tumour cells is thought to initiate their eradication via a process termed immunogenic cell death (ICD). Methods We treated OC cells with the chemotherapeutic—doxorubicin...
Paper Details
Title
Endoplasmic reticulum stress-induced release and binding of calreticulin from human ovarian cancer cells
Published Date
Nov 20, 2021
Volume
71
Issue
7
Pages
1655 - 1669
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Notes
History