Cancer Immunology, Immunotherapy
Papers 5,947
1 page of 595 pages (5,947 results)
#1Trefa M Abdullah (University of Exeter)H-Index: 4
#2Jacqueline L. Whatmore (University of Exeter)H-Index: 25
Last. Paul Eggleton (University of Exeter)H-Index: 45
view all 6 authors...
Calreticulin (CRT) is an endoplasmic reticulum (ER) chaperone, but can appear surface bound on cancers cells, including ovarian cancers (OC). We investigated at what stage of cell viability, CRT appeared associated with surface of human OC cells. CRT on pre-apoptotic tumour cells is thought to initiate their eradication via a process termed immunogenic cell death (ICD). We treated OC cells with the chemotherapeutic—doxorubicin (DX) known to induce translocation of CRT to some tumour cell surface...
#1Yang Shen (Army Medical University)H-Index: 1
#2Xiao-long Li (Army Medical University)
Last. Liu-sheng Peng (Army Medical University)H-Index: 16
view all 14 authors...
CD8+CD103+ tissue-resident memory T cells (TRMs) are involved in tumor immune response and linked to favorable clinical outcome in human cancer. However, the distribution, phenotype, functional properties and clinical relevance of these cells in gastric cancer (GC) remain elusive. Here, our data show that, in comparison to non-tumor tissues, the percentages of CD8+CD103+ TRMs in tumors are significantly decreased. Most tumor-infiltrating CD8+CD103+ TRMs are CD45RA−CCR7− effector-memory cells wit...
#1Audrey Page (UCBL: Claude Bernard University Lyon 1)H-Index: 2
#2Emilie Laurent (UCBL: Claude Bernard University Lyon 1)H-Index: 1
Last. Floriane Fusil (UCBL: Claude Bernard University Lyon 1)H-Index: 15
view all 8 authors...
Here, we report a novel experimental setup to perform adoptive transfer of gene-edited B cells using humanized immune system mice by infusing autologous HIS mouse-derived human B cells "educated" in a murine context and thus rendered tolerant to the host. The present approach presents two advantages over the conventional humanized PBMC mouse models: (i) it circumvents the risk of xenogeneic graft-versus-host reaction and (ii) it mimics more closely human immune responses, thus favoring clinical ...
#1Jun-Shuai Xue (SDU: Shandong University)
#2Hui Liu (SDU: Shandong University)
Last. Tao Li (SDU: Shandong University)H-Index: 117
view all 11 authors...
Preliminary studies have suggested that soluble programmed death-1 (sPD-1) and soluble programmed cell death ligand-1 (sPD-L1) have prognostic implications in many malignant tumors. However, the correlation between sPD-1/sPD-L1 level and prognosis of hepatocellular carcinoma (HCC) is still unclear. We searched several electronic databases from database inception to October 7, 2021. Meta-analyses were performed separately for overall survival (OS), disease-free survival (DFS), recurrence-free sur...
#1Xiangling Chu (Tongji University)H-Index: 3
#2Huiping Qiang (Shanghai Chest Hospital)
Last. Chunxia Su (Tongji University)H-Index: 25
view all 12 authors...
Despite the remarkable clinical advance of immune checkpoint inhibitors (ICIs) in the treatment of lung cancer, there are limited studies focused on evaluating efficacy of ICIs for patients with human epidermal growth factor receptor 2 (HER2)-mutant lung adenocarcinoma. We conducted a multicenter retrospective study of patients with HER2-mutant lung adenocarcinoma who received ICIs therapy at Shanghai Pulmonary Hospital, Shanghai Chest Hospital and the First Affiliated Hospital of Wenzhou Medica...
#1Chuan Liu (CMU: China Medical University)H-Index: 2
#2Guangwei Zhang (CMU: China Medical University)H-Index: 1
Last. Ti Wen
view all 7 authors...
Immune checkpoint inhibitors (ICIs) for programmed death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) have become preferred treatment strategies for several advanced cancers. However, response rates for these treatments are limited, which encourages the search for new ICI candidates. Recent reports have underscored significant roles of B7 homolog 3 protein (B7-H3) in tumor immunity and disease progression. While its multifaceted roles are being elucidated, B7-H3 has already entered clinic...
#1Luya Cai (First Affiliated Hospital of Wenzhou Medical University)H-Index: 3
#2Xuedan Du (First Affiliated Hospital of Wenzhou Medical University)H-Index: 3
Last. Wenfeng Li (First Affiliated Hospital of Wenzhou Medical University)H-Index: 8
view all 14 authors...
Recently, the emergence of immunotherapy has revolutionized traditional tumour treatment. However, effective treatments for patients exhibiting αPD-1 resistance are still lacking. In our study, a combination of cytosine-phosphate-guanine oligodeoxynucleotides (CpG-ODNs), anti-OX40 and cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) injection in situ systematically generated a robust antitumour immune response in TC1 and B16 cells, which are αPD-1-resistant malignancies. More preci...
#1Bharat Kumar Reddy Chaganty (The University of Texas MD Anderson Cancer Center)H-Index: 10
#2Songbo Qiu (The University of Texas MD Anderson Cancer Center)H-Index: 11
Last. Zhen Fan (The University of Texas MD Anderson Cancer Center)H-Index: 44
view all 6 authors...
We tested the concept that host preexisting influenza A virus immunity can be redirected to inhibit tumor growth and metastasis through systemic administration of influenza A virus-related peptides to targeted tumors. Mice infected with influenza A virus strain A/Puerto Rico/8/34 (PR8) were used as a model of a host with preexisting viral immunity. The extent to which preexisting influenza A immunity in PR8-immunized mice can be redirected to inhibit tumor growth and metastasis was first examine...
#1Luciana Gneo (University of Birmingham)H-Index: 1
#2Nagy Rizkalla (University of Birmingham)H-Index: 1
Last. Gary Middleton (University of Birmingham)H-Index: 52
view all 6 authors...
Monocytic myeloid-derived suppressor cells (M-MDSCs) are significantly expanded in the blood of colorectal cancer (CRC) patients. However, their presence and underlying mechanisms in the tumour microenvironment of CRC have not been examined in detail. Tumour tissues and peripheral blood from CRC patients were analysed for the presence of M-MDSCs. The mechanisms of suppression were analysed by blocking pathways by which MDSCs abrogate T cell proliferation. Co-culture of CRC cells with monocytes w...
#1Łukasz Zadka (Wrocław Medical University)H-Index: 7
#2Mariusz Chabowski (Wrocław Medical University)H-Index: 16
Last. Piotr Dziegiel (Wrocław Medical University)H-Index: 29
view all 5 authors...
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