A defective viral genome strategy elicits broad protective immunity against respiratory viruses
Abstract
RNA viruses generate defective viral genomes (DVGs) that can interfere with replication of the parental wild-type virus. To examine their therapeutic potential, we created a DVG by deleting the capsid-coding region of poliovirus. Strikingly, intraperitoneal or intranasal administration of this genome, which we termed eTIP1, elicits an antiviral response, inhibits replication, and protects mice from several RNA viruses, including enteroviruses,...
Paper Details
Title
A defective viral genome strategy elicits broad protective immunity against respiratory viruses
Published Date
Dec 1, 2021
Journal
Volume
184
Issue
25
Pages
6037 - 6051.e14
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