Structural Evolution of TIR-Domain Signalosomes
Abstract
TIR (Toll/interleukin-1 receptor/resistance protein) domains are cytoplasmic domains widely found in animals and plants, where they are essential components of the innate immune system. A key feature of TIR-domain function in signaling is weak and transient self-association and association with other TIR domains. An additional new role of TIR domains as catalytic enzymes has been established with the recent discovery of NAD+-nucleosidase...
Paper Details
Title
Structural Evolution of TIR-Domain Signalosomes
Published Date
Nov 17, 2021
Journal
Volume
12
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Notes
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