Childhood trauma, antipsychotic medication, and symptom remission in first-episode psychosis

To what extent psychotic symptoms in first-episode psychosis (FEP) with a history of childhood interpersonal trauma (CIT) are less responsive to antipsychotic medication is not known. In this longitudinal study, we compare symptom trajectories and remission over the first 2 years of treatment in FEP with and without CIT and examine if differences are linked to the use of antipsychotics.FEP (N = 191) were recruited from in- and outpatient...