Original paper

OTUB1 regulates lung development, adult lung tissue homeostasis, and respiratory control

Volume: 35, Issue: 12
Published: Nov 18, 2021
Abstract
OTUB1 is one of the most highly expressed deubiquitinases, counter-regulating the two most abundant ubiquitin chain types. OTUB1 expression is linked to the development and progression of lung cancer and idiopathic pulmonary fibrosis in humans. However, the physiological function of OTUB1 is unknown. Here, we show that constitutive whole-body Otub1 deletion in mice leads to perinatal lethality by asphyxiation. Analysis of (single-cell) RNA...
Paper Details
Title
OTUB1 regulates lung development, adult lung tissue homeostasis, and respiratory control
Published Date
Nov 18, 2021
Volume
35
Issue
12
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