Systemic IL-15 promotes allogeneic cell rejection in patients treated with natural killer cell adoptive therapy
Abstract
Natural killer (NK) cells are a promising alternative to T cells for cancer immunotherapy. Adoptive therapies with allogeneic, cytokine-activated NK cells are being investigated in clinical trials. However, the optimal cytokine support after adoptive transfer to promote NK cell expansion, and persistence remains unclear. Correlative studies from 2 independent clinical trial cohorts treated with major histocompatibility complex-haploidentical NK...
Paper Details
Title
Systemic IL-15 promotes allogeneic cell rejection in patients treated with natural killer cell adoptive therapy
Published Date
Feb 24, 2022
Journal
Volume
139
Issue
8
Pages
1177 - 1183
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