A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice
Abstract
As SARS-CoV-2 continues to cause morbidity and mortality around the world, there is an urgent need for the development of effective medical countermeasures. Here, we assessed the antiviral capacity of a minimal RIG-I agonist, stem-loop RNA 14 (SLR14), in viral control, disease prevention, post-infection therapy, and cross-variant protection in mouse models of SARS-CoV-2 infection. A single dose of SLR14 prevented viral infection in the lower...
Paper Details
Title
A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice
Published Date
Nov 10, 2021
Volume
219
Issue
1
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