Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer

Volume: 20, Issue: 1
Published: Nov 6, 2021
Abstract
Colorectal cancer (CRC) is a heterogeneous disease at the cellular and molecular levels. Kirsten rat sarcoma (KRAS) is a commonly mutated oncogene in CRC, with mutations in approximately 40% of all CRC cases; its mutations result in constitutive activation of the KRAS protein, which acts as a molecular switch to persistently stimulate downstream signaling pathways, including cell proliferation and survival, thereby leading to tumorigenesis....
Paper Details
Title
Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer
Published Date
Nov 6, 2021
Volume
20
Issue
1
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