Original paper
Kinetochore life histories reveal an Aurora-B-dependent error correction mechanism in anaphase
Abstract
Chromosome mis-segregation during mitosis leads to aneuploidy, which is a hallmark of cancer and linked to cancer genome evolution. Errors can manifest as "lagging chromosomes" in anaphase, although their mechanistic origins and likelihood of correction are incompletely understood. Here, we combine lattice light-sheet microscopy, endogenous protein labeling, and computational analysis to define the life history of >104 kinetochores. By defining...
Paper Details
Title
Kinetochore life histories reveal an Aurora-B-dependent error correction mechanism in anaphase
Published Date
Nov 1, 2021
Journal
Volume
56
Issue
22
Pages
3082 - 3099.e5
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Notes
History