Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas
Abstract
Somatic mutations in APC or CTNNB1 genes lead to aberrant Wnt signaling and colorectal cancer (CRC) initiation and progression via-catenin–T cell factor/lymphoid enhancer binding factor TCF/LEF transcription factors. We found that Lef1 was expressed exclusively in Apc-mutant, Wnt ligand–independent tumors, but not in ligand-dependent, serrated tumors. To analyze Lef1 function in tumor development, we conditionally deleted Lef1 in intestinal stem...
Paper Details
Title
Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas
Published Date
Nov 19, 2021
Journal
Volume
7
Issue
47
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