Review paper
Advances toward structure-based drug discovery for inflammasome targets
Abstract
Inflammasome proteins play an important role in many diseases of high unmet need, making them attractive drug targets. However, drug discovery for inflammasome proteins has been challenging in part due to the difficulty in solving high-resolution structures using cryo-EM or crystallography. Recent advances in the structural biology of NLRP3 and NLRP1 have provided the first set of data that proves a promise for structure-based drug design for...
Paper Details
Title
Advances toward structure-based drug discovery for inflammasome targets
Published Date
Nov 16, 2021
Volume
219
Issue
1