Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids
Abstract
Although alveolar epithelial cells play a critical role in the pathogenesis of pulmonary fibrosis, few practical in vitro models exist to study them. Here, we established a novel in vitro pulmonary fibrosis model using alveolar organoids consisting of human pluripotent stem cell-derived alveolar epithelial cells and primary human lung fibroblasts. In this human model, bleomycin treatment induced phenotypes such as epithelial cell-mediated...
Paper Details
Title
Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids
Published Date
Dec 1, 2021
Journal
Volume
16
Issue
12
Pages
2973 - 2987
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Notes
History