Stem cell reports
Papers 1,989
1 page of 199 pages (1,989 results)
#1Takahiro Suezawa (Kyoto University)H-Index: 2
#2Shuhei KanagakiH-Index: 2
Last. Shimpei Gotoh (Kyoto University)H-Index: 10
view all 12 authors...
Summary null Although alveolar epithelial cells play a critical role in the pathogenesis of pulmonary fibrosis, few practical in vitro models exist to study them. Here, we established a novel in vitro pulmonary fibrosis model using alveolar organoids consisting of human pluripotent stem cell-derived alveolar epithelial cells and primary human lung fibroblasts. In this human model, bleomycin treatment induced phenotypes such as epithelial cell-mediated fibroblast activation, cellular senescence, ...
#1Ning Xie (UMN: University of Minnesota)H-Index: 5
#2Sabrina N. Chu (UMN: University of Minnesota)
Last. Sunny Sun Kin Chan (UMN: University of Minnesota)H-Index: 17
view all 8 authors...
Summary null One major challenge in realizing cell-based therapy for treating muscle-wasting disorders is the difficulty in obtaining therapeutically meaningful amounts of engraftable cells. We have previously described a method to generate skeletal myogenic progenitors with exceptional engraftability from pluripotent stem cells via teratoma formation. Here, we show that these cells are functionally expandable in vitro while retaining their in vivo regenerative potential. Within 37 days in cultu...
#1Qian Li (ZJU: Zhejiang University)H-Index: 1
#2Junchen Chen (ZJU: Zhejiang University)H-Index: 5
Last. Xuekun LiH-Index: 25
view all 11 authors...
RYBP (Ring1 and YY1 binding protein), an essential component of the Polycomb repressive complex 1 (PRC1), plays pivotal roles in development and diseases. However, the roles of Rybp in neuronal development remains completely unknown. In the present study, we have shown that the depletion of Rybp inhibits proliferation and promotes neuronal differentiation of embryonic neural progenitor cells (eNPCs). In addition, Rybp deficiency impairs the morphological development of neurons. Mechanistically, ...
#1Rachel Herndon Klein (Shriners Hospitals for Children)H-Index: 3
#2Paul S. Knoepfler (Shriners Hospitals for Children)H-Index: 46
Many gene networks are shared between pluripotent stem cells and cancer; a concept exemplified by several DPPA factors such as DPPA2 and DPPA4, which are highly and selectively expressed in stem cells but also found to be reactivated in cancer. Despite their striking expression pattern, for many years the function of DPPA2 and DPPA4 remained a mystery; knockout of Dppa2 and Dppa4 did not affect pluripotency, but caused lung and skeletal defects late in development, long after Dppa2 and Dppa4 exp...
#1Margaret Cook (ASU: Arizona State University)
#2Alexandra Richey (ASU: Arizona State University)
Last. Emma Frow (ASU: Arizona State University)H-Index: 13
view all 4 authors...
Hundreds of businesses across the United States offer direct-to-consumer stem-cell-based interventions that have not been approved by the Food and Drug Administration. Here, we characterize the types of evidence used on the websites of 59 stem cell businesses in the Southwest United States to market their services. We identify over a dozen forms of evidence, noting that businesses are less likely to rely on "gold-standard" scientific evidence, like randomized clinical trials, and instead draw su...
#1Seema C. Namboori (University of Exeter)H-Index: 2
#2Patricia Thomas (University of Birmingham)H-Index: 1
Last. Akshay Bhinge (University of Exeter)H-Index: 18
view all 9 authors...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by the loss of motor neurons. We utilized single-cell transcriptomics to uncover dysfunctional pathways in degenerating motor neurons differentiated from SOD1 E100G ALS patient-derived induced pluripotent stem cells (iPSCs) and respective isogenic controls. Differential gene expression and network analysis identified activation of developmental pathways and core transcriptional factors driving the ALS motor ...
#1Beatrice Xuan Ho (Agency for Science, Technology and Research)H-Index: 8
#2Hongbing Yu (Agency for Science, Technology and Research)
Last. Boon Seng Soh (Agency for Science, Technology and Research)H-Index: 20
view all 13 authors...
Summary null The immature characteristics and metabolic phenotypes of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) restrict their applications for disease modeling, drug discovery, and cell-based therapy. Leveraging on the metabolic shifts from glycolysis to fatty acid oxidation as CMs mature, a human hexokinase1-GFP metabolic reporter cell line (H7 HK1-GFP) was generated to facilitate the isolation of fetal or more matured hPSC-CMs. RNA sequencing of fetal versus more matured C...
#1Yusuke Ito (Japan Society for the Promotion of Science)H-Index: 3
#2Fumio Nakahara (UTokyo: University of Tokyo)H-Index: 20
Last. Mineo Kurokawa (UTokyo: University of Tokyo)H-Index: 70
view all 4 authors...
Summary null null Hematopoietic cells differentiate through several progenitors in a hierarchical manner, and recent single-cell analyses have revealed substantial heterogeneity within each progenitor. Although common myeloid progenitors (CMPs) are defined as a multipotent cell population that can differentiate into granulocyte-monocyte progenitors (GMPs) and megakaryocyte-erythrocyte progenitors (MEPs), and GMPs generate neutrophils and monocytes, these myeloid progenitors must contain some lin...
#1Alice Vickers ('KCL': King's College London)H-Index: 3
#2Mukul Tewary ('KCL': King's College London)H-Index: 1
Last. Fiona M. Watt ('KCL': King's College London)H-Index: 125
view all 8 authors...
Summary null Quantitative analysis of human induced pluripotent stem cell (iPSC) lines from healthy donors is a powerful tool for uncovering the relationship between genetic variants and cellular behavior. We previously identified rare, deleterious non-synonymous single nucleotide variants (nsSNVs) in cell adhesion genes that are associated with outlier iPSC phenotypes in the pluripotent state. Here, we generated micropatterned colonies of iPSCs to test whether nsSNVs influence patterning of rad...
#1Leigh Turner (UCI: University of California, Irvine)
#2Megan Munsie (University of Melbourne)H-Index: 21
Last. Laertis Ikonomou (SUNY: State University of New York System)H-Index: 16
view all 4 authors...
The significant morbidity and mortality of coronavirus disease 19 (COVID-19) prompted a global race to develop new therapies. These include interventions using cell- or cell-derived products, several of which are being tested in well-designed, properly controlled clinical trials. Yet, the search for cell-based COVID-19 treatments has also been fraught with hyperbolic claims; flouting of crucial regulatory, scientific, and ethical norms; and distorted communication of research findings. In this p...
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