Original paper
1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development
Abstract
Identification of physiological modulators of nuclear hormone receptor (NHR) activity is paramount for understanding the link between metabolism and transcriptional networks that orchestrate development and cellular physiology. Using libraries of metabolic enzymes alongside their substrates and products, we identify 1-deoxysphingosines as modulators of the activity of NR2F1 and 2 (COUP-TFs), which are orphan NHRs that are critical for...
Paper Details
Title
1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development
Published Date
Nov 1, 2021
Journal
Volume
56
Issue
22
Pages
3128 - 3145.e15
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Notes
History