Achievement of Near-Normal HbA1c With Early Initiation of Oral Semaglutide: An Exploratory Subgroup Analysis of PIONEER 1

Early achievement of near-normal HbA1c is associated with a reduced risk of future complications in type 2 diabetes (T2D) and may help motivate patients (pts) to maintain treatment. We conducted a post-hoc analysis of the PIONEER 1 study to look at the impact of early initiation of oral semaglutide (sema) on glycemic efficacy, body weight (BW), and achievement of targets. Pts on diet and exercise were randomized to oral sema 3, 7, or 14 mg once...