Melanie J. Davies
University of Leicester
Internal medicineEndocrinologySurgeryDemographyRandomized controlled trialIntensive care medicinePhysical therapyPediatricsType 2 diabetesDiseaseInsulinBody mass indexImpaired glucose tolerancePopulationType 2 Diabetes MellitusFamily medicineWeight lossDiabetes mellitusMedicineGerontology
951Publications
95H-index
30kCitations
Publications 951
Newest
#1Winston Crasto (National Health Service)
#2Vinod Patel (Warw.: University of Warwick)H-Index: 17
Last. Kamlesh Khunti (Leicester General Hospital)H-Index: 96
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Microvascular complications of diabetes present a significant challenge due to their diverse presentations, significant morbidity, and as strong predictors of cardiovascular disease. Prevention and management strategies should focus on lifestyle modification, education and awareness, systematic screening for early complications, and intensive management of modifiable risk factors. This review discusses the microvascular complications of diabetes, including diabetic retinopathy, diabetic kidney d...
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#1Alex Rowlands (University Hospitals of Leicester NHS Trust)H-Index: 1
#2Paddy C. DempseyH-Index: 20
Last. Tom Norris (Leicester General Hospital)
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Abstract null Objective null To quantify the association between accelerometer-assessed physical activity and COVID-19 outcomes. null Patients and Methods null Data from 82,253 UK Biobank participants with accelerometer data (measured 2013-2015), complete covariate data, and linked COVID-19 data from 16th March 2020 to 16th March 2021 were included. Two outcomes were investigated: severe COVID-19 (positive test from in-hospital setting or COVID-19 as primary cause of death); non-severe COVID-19 ...
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#1Jo Byrne (University Hospitals of Leicester NHS Trust)H-Index: 5
#2Andrew Willis (University of Leicester)H-Index: 5
Last. Kamlesh Khunti (University of Leicester)H-Index: 96
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AIMS To review and synthesise the contemporary qualitative evidence, relating to the individual, healthcare professional and system-level barriers and facilitators to injectable therapies in people with type 2 diabetes, and evaluate (using an intersectional approach to explore the diverse perspectives of different identities) whether views have changed with treatment and guideline advancements. METHODS A meta-ethnography approach used. Eight databases searched from the years 2006 (GLP-1 analogue...
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#1Petra J. Jones (Leicester General Hospital)H-Index: 3
#2Michael Catt (Newcastle University)H-Index: 20
Last. Alex V. Rowlands (Leicester General Hospital)H-Index: 29
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Abstract null null Background null Identifying clusters of physical activity (PA) from accelerometer data is important to identify levels of sedentary behaviour and physical activity associated with risks of serious health conditions and time spent engaging in healthy PA. Unsupervised machine learning models can capture PA in everyday free-living activity without the need for labelled data. However, there is scant research addressing the selection of features from accelerometer data. The aim of ...
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#1John B. Buse (UNC: University of North Carolina at Chapel Hill)H-Index: 118
#2Melanie J. Davies (University of Leicester)H-Index: 95
Last. Athena Philis-Tsimikas (Scripps Health)H-Index: 26
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Throughout history, up to the early part of the 20th century, diabetes has been a devastating disorder, particularly when diagnosed in childhood when it was usually fatal. Consequently, the successful pancreatic extraction of insulin in 1921 was a miraculous, life-changing advance. In this review, the truly transformative effect that insulin has had on the lives of people with type 1 diabetes and on those with type 2 diabetes who are also dependent on insulin is described, from the time of its f...
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#1Thomas Yates (NIHR: National Institute for Health Research)H-Index: 50
#2Francesco Zaccardi (University of Leicester)H-Index: 33
Last. Annemarie B Docherty (Edin.: University of Edinburgh)H-Index: 19
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BACKGROUND: Although age, obesity and pre-existing chronic diseases are established risk factors for COVID-19 outcomes, their interactions have not been well researched. METHODS: We used data from the Clinical Characterisation Protocol UK (CCP-UK) for Severe Emerging Infection developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC). Patients admitted to hospital with COVID-19 from 6th February to 12th October 2020 were included where there was a coded ...
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#1Yogini Chudasama (Leicester General Hospital)H-Index: 8
#2Francesco Zaccardi (Leicester General Hospital)H-Index: 33
Last. Kamlesh Khunti (Leicester General Hospital)H-Index: 96
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Objective null To investigate factors associated with delays in receiving glucose-lowering therapy in patients newly diagnosed with type 2 diabetes mellitus (T2DM), and explore the preferential order and time of intensifications. null Methods null Retrospective cohort study including 120 409 adults with T2DM initiating first to fourth-line glucose-lowering therapy in primary care between 2000 and 2018, using the UK Clinical Practice Research Datalink linked to Hospital Episode Statistics, Office...
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#1Thomas Yates (NIHR: National Institute for Health Research)H-Index: 50
#2Annabel Summerfield (Office for National Statistics)H-Index: 2
Last. Evgeny M. Mirkes (University of Leicester)H-Index: 10
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Abstract null Importance null Obesity and ethnicity are well characterised risk factors for severe COVID-19 outcomes, but the differential effects of obesity on COVID-19 outcomes by race/ethnicity has not been examined robustly in the general population. null Objective null To investigate the association between body mass index (BMI) and COVID-19 mortality across different ethnic groups. null Design, Setting, and Participants null This is a retrospective cohort study using linked national Census...
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#1Gaurav S. Gulsin (University of Leicester)H-Index: 10
#2Emer M. Brady (NIHR: National Institute for Health Research)H-Index: 12
Last. David R. Webb (University of Leicester)H-Index: 27
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Background:There is a high prevalence of asymptomatic (American Heart Association Stage B) heart failure (SBHF) in people with type 2 diabetes (T2D). We aimed to identify associations between clini...
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#2Jorge Correia (University of Geneva)H-Index: 5
Last. Melanie J. Davies (University of Leicester)H-Index: 95
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BACKGROUND Diabetes Self-Management Education and Support (DSMES) programmes are vital for type 2 diabetes mellitus (T2DM) management. However, they are limited in Sub-Saharan Africa (SSA). To address this gap, a DSMES, namedEXTEND was developed in Lilongwe (Malawi) and Maputo (Mozambique). This qualitative study aimed to explore factors that influence the implementation of DSMES in these settings. METHODS The Socio-ecological model was applied to explore factors influencing the implementation o...
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