Genome-Guided Discovery of Highly Oxygenated Aromatic Polyketides, Saccharothrixins D–M, from the Rare Marine Actinomycete Saccharothrix sp. D09

Angucyclines and angucyclinones are aromatic polyketides with intriguing structures and therapeutic value. Genome mining of the rare marine actinomycete Saccharothrix sp. D09 led to the identification of a type II polyketide synthase biosynthetic gene cluster, sxn, which encodes several distinct subclasses of oxidoreductases, implying that this strain has the potential to produce novel polycyclic aromatic polyketides with unusual redox...