Journal of Natural Products
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#1Chunyang Zhang (SDU: Shandong University)H-Index: 5
#2Zhao-Jun Chu (SDU: Shandong University)
Last. Hong-Xiang Lou (SDU: Shandong University)H-Index: 43
view all 7 authors...
Ten new triterpenoids, including nine 9,10-seco-cycloartanes (1-9) and one 9,19-cyclolanostane (10), as well as one sesquiterpenoid (11) and four known compounds (12-15), were extracted and purified from the whole plant of the Chinese liverwort Lepidozia reptans. Multiple techniques (NMR, HRESIMS, IR, and X-ray crystallographic analysis) were applied to determine the structures of the isolated compounds. Bioassay determinations showed that compound 7, which contains an α,β-unsaturated carbonyl m...
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#1Thi-Phuong Doan (SNU: Seoul National University)H-Index: 2
#2Eun-Jin Park (SNU: Seoul National University)H-Index: 8
Last. Won Keun Oh (SNU: Seoul National University)H-Index: 42
view all 7 authors...
Rugonidines A-F (1-6), three pairs of novel configurationally semistable diastereomers featuring an unprecedented 1,6-dioxa-7,9-diazaspiro[4.5]dec-7-en-8-amine scaffold, were isolated from Alchornea rugosa based on MS/MS-based molecular networking analysis. Their structures were elucidated by NMR spectroscopy in combination with quantum-chemical calculations. Compounds 1-3 showed a significant increase in glucose uptake level in differentiated 3T3-L1 adipocytes using 2-deoxy-2-[(7-nitro-2,1,3-be...
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#1Xiao-Zhen Wu (Lanzhou University)
#2Wen-Jun Huang (Lanzhou University)H-Index: 2
Last. Changsheng Zhang (CAS: Chinese Academy of Sciences)H-Index: 35
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Penicisteckins A-D (1-4), two pairs of atropodiastereomeric biaryl-type hetero- and homodimeric bis-isochromans with 7,5'- and 7,7'-linkages and a pair of atropodiastereomeric 2-(isochroman-5-yl)-1,4-benzoquinone derivatives [penicisteckins E (5) and F (6)], were isolated from the Penicillium steckii HNNU-5B18. Their structures including the absolute configuration were determined by extensive spectroscopic and single-crystal X-ray diffraction analysis and TDDFT-ECD calculations. Both the bis-iso...
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#1Dale W. Prebble (Griffith University)H-Index: 1
#2Mingming Xu (Griffith University)H-Index: 4
Last. Anthony Richard Carroll (Griffith University)H-Index: 42
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During a recent biodiscovery study to identify new α-synuclein (α-syn) aggregation inhibitors, we screened 29 Australian marine sponge and ascidian extracts in an MS binding assay. This resulted in an extract from the ascidian Sycozoa cerebriformis showing activity toward α-syn. The bioassay and MS guided isolation process led to the identification of one new polyoxygenated sterol sulfate, sycosterol A (1). The structure of this low-yielding steroid was elucidated from HRMS and NMR analysis. Syc...
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#1Alexis St-Gelais (UQAC: Université du Québec à Chicoutimi)H-Index: 4
#2Jérôme Alsarraf (UQAC: Université du Québec à Chicoutimi)H-Index: 5
Last. André Pichette (UQAC: Université du Québec à Chicoutimi)H-Index: 31
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Dirchromone is a bioactive vinyl sulfoxide-bearing chromone first isolated from the shrub Dirca palustris. Altogether, 32 of its derivatives were prepared to assess the effect of substitution of its chromone core upon activities against cancer cell lines, Gram-positive bacteria, and fungi (such as Candida albicans). All compounds were synthesized following a synthetic strategy involving Pummerer and soft-enolization Baker-Venkataraman rearrangements. Substituent position changes induced little v...
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#1Qiyao Shen (SDU: Shandong University)H-Index: 2
#2Guangzhi Dai (SDU: Shandong University)H-Index: 1
Last. Haibo Zhou (SDU: Shandong University)H-Index: 5
view all 13 authors...
Angucyclines and angucyclinones are aromatic polyketides with intriguing structures and therapeutic value. Genome mining of the rare marine actinomycete Saccharothrix sp. D09 led to the identification of a type II polyketide synthase biosynthetic gene cluster, sxn, which encodes several distinct subclasses of oxidoreductases, implying that this strain has the potential to produce novel polycyclic aromatic polyketides with unusual redox modifications. The "one strain-many compounds" (OSMAC) strat...
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#1Zewei Chen (Ohio University - Lancaster)H-Index: 5
#2Peter de B. Harrington (Ohio University - Lancaster)H-Index: 34
view all 4 authors...
Cannabidiol (CBD, 1) is an active component of hemp oil and many other products that offers diverse health benefits. Near-infrared spectroscopy (NIRS) coupled with chemometrics was utilized to quantify the CBD (1) concentration in the hemp oil through the containing glass vial. NIRS provided a fast and cost-effective tool to measure chemical profiles for the hemp oil samples with various concentrations of CBD (1) and its acid precursor, i.e., cannabidiolic acid (CBDA, 2). The measured NIR spectr...
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#1Yoshinori Asakawa (Tokushima Bunri University)H-Index: 63
#2Agnieszka Ludwiczuk (MUL: Medical University of Lublin)H-Index: 16
Last. Kenneth Yongabi Anchang (CATUC: Catholic University of Cameroon)H-Index: 4
view all 5 authors...
The Marchantiophyta (liverworts) are rich sources of phenolic substances, especially cyclic and acyclic bis-bibenzyls, which are rare natural products in the plant kingdom, together with bibenzyls and characteristic terpenoids. At present, more than 125 bis-bibenzyls have been found in liverworts. They are biosynthesized from the dimerization of lunularic acid via dihydrocoumaric acid and prelunularin. The structurally unusual cyclic and acyclic bis-bibenzyls show various biological activities s...
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#1Hai-Wei Yan (CAMS&PUMC: Chinese Academy of Medical Sciences & Peking Union Medical College)H-Index: 2
#2Ling-Hao Zhao (CAMS&PUMC: Chinese Academy of Medical Sciences & Peking Union Medical College)
Last. Pei-Cheng Zhang (CAMS&PUMC: Chinese Academy of Medical Sciences & Peking Union Medical College)H-Index: 22
view all 6 authors...
Arnebinones B, E, and D (1-3) have been found to be sensitive to light, generating complex and diverse proton transfer products when triggered by light. A unique two-step irreversible intramolecular proton transfer of 1 produced five scalemic mixtures, of which four possessed intriguing dual planar chirality. The unprecedented orientation epimerization equilibrium of the intra-annular double bond was first observed and researched in the homologous meroterpenoids by HPLC monitoring and DFT calcul...
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#1Xiaomeng Hao (CAMS&PUMC: Chinese Academy of Medical Sciences & Peking Union Medical College)H-Index: 4
#2Shasha Li (CAMS&PUMC: Chinese Academy of Medical Sciences & Peking Union Medical College)H-Index: 2
Last. Maoluo Gan (CAMS&PUMC: Chinese Academy of Medical Sciences & Peking Union Medical College)H-Index: 18
view all 9 authors...
Six new 16-residue peptaibols, acremopeptaibols A-F (1-6), along with five known compounds, were isolated from the cultures of the sponge-associated fungus Acremonium sp. IMB18-086 grown in the presence of the autoclaved bacterium Pseudomonas aeruginosa on solid rice medium. The peptaibol sequences were established based on comprehensive analysis of 1D and 2D NMR spectroscopic data in conjunction with HRESIMS/MS experiments. The configurations of the amino acid residues were determined by advanc...
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