Journal of Natural Products
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#1Khong Trong Quan (CNU: Chungnam National University)H-Index: 6
#2InWha Park (KIST: Korea Institute of Science and Technology)
Last. Joonseok Oh (Yale University)H-Index: 17
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A new benzo[g]isochromene possessing a conformationally mobile moiety was identified from Rubia philippinensis. The 2D structure was established utilizing spectrometric and spectroscopic techniques with variable temperatures. The configurational investigation of the flexible moiety was investigated utilizing contemporary NMR-combined computational tools such as DP4, direct J-DP4, and DP4 Plus. The probabilities computed from DP4 Plus analysis, featuring inclusion of an additional geometry optimi...
#1Chun-Xiao Jiang (Lanzhou University)H-Index: 3
#2Bo Yu (Lanzhou University)H-Index: 1
Last. Xiaolei Wang (Lanzhou University)
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Clonorosins A (1) and B (2), two novel indole alkaloids featuring unprecedented 6/5/6/6/5 and 6/5/5 cores, together with seven known indole-linked 2,5-diketopiperazine alkaloids (3-9), were isolated from the soil-derived fungus Clonostachys rosea YRS-06. The new structures were proposed through HR-MS, NMR, and ECD spectroscopic data. They were established by comparing the calculated NMR, ECD, and specific rotation data with the experimental. To assist in determining the absolute configuration of...
#1Enjing Jin (Ocean University of China)H-Index: 1
#2Huayue Li (Ocean University of China)H-Index: 6
Last. Wenli Li (Ocean University of China)H-Index: 7
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Two new (1 and 2) along with six known (3-8) dixiamycins were isolated from the culture broth of a cold-seep-derived actinomycete, Streptomyces olivaceus OUCLQ19-3. Structures of the isolated compounds were elucidated based on extensive MS and NMR spectroscopic analyses together with ECD calculations. In the antibacterial test, compounds 1-8 exhibited notable growth inhibitions against a panel of multi-drug-resistant (MDR) strains with MIC values of 0.78-6.25 μg/mL, among which 1, 2, and 5-7 wer...
#1Jung Ho Lee (UIC: University of Illinois at Chicago)H-Index: 2
#2Julia R. Austin (UIC: University of Illinois at Chicago)H-Index: 2
Last. Brian T. Murphy (UIC: University of Illinois at Chicago)H-Index: 16
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The use of botanical dietary supplements for the alleviation of conditions such as hot flashes, premenstrual syndrome, and fertility is prolific worldwide. Estrogen and progesterone receptors (ER and PR) and their corresponding steroid hormones are critical for the relief of hot flashes and the treatment of patients who develop endometriosis, and these pathways can influence the development of endometrial, ovarian, and breast cancers. However, few studies have investigated or identified the natu...
To identify novel bioactive compounds, an image-based, cell culture screening of natural product extracts was conducted. Specifically, our screen was designed to identify phytochemicals that might phenocopy inhibition of the chromosomal passenger protein complex in eliciting mitotic and cytokinetic defects. A known alkaloid, scoulerine, was identified from the rhizomes of the plant Corydalis decumbens as being able to elicit a transient mitotic arrest followed by either apoptosis induction or po...
#1Mi Zhang (Toho University)H-Index: 1
#2Kouharu Otsuki (Toho University)H-Index: 1
Last. Ning Li (SPU: Shenyang Pharmaceutical University)H-Index: 28
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Structurally diverse tigliane diterpenoids have drawn significant research interest for drug discovery over many decades. Using LC-MS-guided fractionation and separation, the first phytochemical investigation on Wikstroemia lamatsoensis led to the isolation of eight tiglianes (1-8), including two new compounds, wikstrocin D (1) and wikstrocin E (2). The new structures were elucidated based on extensive physicochemical and spectroscopic analyses. The characteristic ESIMS/MS fragmentations of tigl...
#1Micaela F. Freitas Misakyan (University of Geneva)
#2E. M. Kithsiri Wijeratne (UA: University of Arizona)H-Index: 25
Last. Muriel Cuendet (University of Geneva)H-Index: 32
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Multiple myeloma (MM) is a hematological cancer in which relapse and resistance are highly frequent. Therefore, alternatives to conventional treatments are necessary. Withaferin A, a withanolide isolated from Withania somnifera, has previously shown promising activity against various MM models. In the present study, structure-activity relationships (SARs) were evaluated using 56 withanolides. The antiproliferative activity was assessed in three MM cell lines and in a 3D MM coculture model to und...
#1Kevin D. Culver (UNC: University of North Carolina at Chapel Hill)
#2Jessie L Allen (USF: University of South Florida)H-Index: 2
Last. Leslie M. Hicks (UNC: University of North Carolina at Chapel Hill)H-Index: 33
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Capsicum spp. (hot peppers) demonstrate a range of interesting bioactive properties spanning anti-inflammatory, antioxidant, and antimicrobial activities. While several species within the genus are known to produce antimicrobial peptides (AMPs), AMP sequence mining of genomic data indicates this space remains largely unexplored. Herein, in silico AMP predictions were paired with peptidomics to identify novel AMPs from the interspecific hybrid ghost pepper (Capsicum chinense × frutescens). AMP pr...
#1Shi-Xing Miao (Southwest Jiaotong University)
#2Lin-Xi Wan (Southwest Jiaotong University)
Last. Feng Gao (Southwest Jiaotong University)H-Index: 5
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The first systematic direct diversification of a complex natural product by metal-catalyzed N-H functionalization was carried out. A new series of N-(hetero)aryl analogues (1-32) of the natural anti-Alzheimer's disease drug huperzine A (HPA) was prepared via palladium-catalyzed Buchwald-Hartwig cross-coupling reactions of HPA with various aryl bromides in good yields. Most of the N-aryl-huperzine A (N-aryl-HPA) analogues showed good acetylcholinesterase (AChE) inhibitory activity in in vitro exp...
#1Erik JacobssonH-Index: 5
#2Steve PeigneurH-Index: 1
Last. Ulf GöranssonH-Index: 1
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