Stereoselective Synthesis of Cyclobutanes by Contraction of Pyrrolidines

Volume: 143, Issue: 45, Pages: 18864 - 18870
Published: Nov 8, 2021
Abstract
Here we report a contractive synthesis of multisubstituted cyclobutanes containing multiple stereocenters from readily accessible pyrrolidines using iodonitrene chemistry. Mediated by a nitrogen extrusion process, the stereospecific synthesis of cyclobutanes involves a radical pathway. Unprecedented unsymmetrical spirocyclobutanes were prepared successfully, and a concise, formal synthesis of the cytotoxic natural product piperarborenine B is...
Paper Details
Title
Stereoselective Synthesis of Cyclobutanes by Contraction of Pyrrolidines
Published Date
Nov 8, 2021
Volume
143
Issue
45
Pages
18864 - 18870
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