Neuroscience

Receptor

Prefrontal cortex

Biology

Neuropeptide

Parvalbumin

Cognition

Psychology

Stimulation

Vasoactive intestinal peptide

Optogenetics

Biochemistry

Neuron

How the dorsomedial prefrontal cortex (dmPFC) computes complex information in social competition within its local network is unclear. Here, Zhang et al. reveal a dynamic disinhibitory microcircuit, involving dmPFC VIP+, PV+, and pyramidal neurons, that controls social competition in the dominance tube test.

Dynamics of a disinhibitory prefrontal microcircuit in controlling social competition