Clinical Effects of Repetitive Transcranial Magnetic Stimulation of the Motor Cortex Are Associated With Changes in Resting-State Functional Connectivity in Patients With Fibromyalgia Syndrome

Repetitive transcranial magnetic stimulation of the motor cortex (M1-rTMS) is a noninvasive therapy for chronic pain,101 including fibromyalgia syndrome (FMS).56,75 Compared to a sham treatment, 2 weeks of daily active M1-rTMS relieves clinical pain, reduces fatigue, increases daily functioning, and improves sleep quality.104 Weekly, bi-weekly, and monthly treatments further increase daily functioning and quality of life (QoL) for 3 to 6...