Original paper
Extracellular ATP and cAMP signaling promote Piezo2‐dependent mechanical allodynia after trigeminal nerve compression injury
Abstract
Trigeminal neuralgia (TN) is a type of severe paroxysmal neuropathic pain commonly triggered by mild mechanical stimulation in the orofacial area. Piezo2, a mechanically gated ion channel that mediates tactile allodynia in neuropathic pain, can be potentiated by a cyclic adenosine monophosphate (cAMP)-dependent signaling pathway that involves the exchange protein directly activated by cAMP 1 (Epac1). To study whether Piezo2-mediated...
Paper Details
Title
Extracellular ATP and cAMP signaling promote Piezo2‐dependent mechanical allodynia after trigeminal nerve compression injury
Published Date
Nov 18, 2021
Journal
Volume
160
Issue
3
Pages
376 - 391
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Notes
History