Algorithm

Acquired resistance

Ecology

Hepatocellular carcinoma

Biology

Telecommunications

Cancer research

Computer science

Resistance (ecology)

Decoding methods

Physics

Liver cancer

Optics

Political science

Internal medicine

Crosstalk

Cancer therapy

MEDLINE

Oncology

Medicine

Cancer

Nature Reviews Gastroenterology & Hepatology

In 2021, our understanding of resistance to therapy in primary liver tumours improved drastically. By taking a holistic approach, three independent studies have characterized the tumour cell biodiversity across space, time and aetiologies in primary liver cancer, decoding the crosstalk between different cell types within the tumour ecosystem and their individual contributions to therapy resistance.

Decoding therapy resistance in liver tumours: a giant leap