Original paper
B cells support the repair of injured tissues by adopting MyD88‐dependent regulatory functions and phenotype
Abstract
Exogenously applied mature naive B220+ /CD19+ /IgM+ /IgD+ B cells are strongly protective in the context of tissue injury. However, the mechanisms by which B cells detect tissue injury and aid repair remain elusive. Here, we show in distinct models of skin and brain injury that MyD88-dependent toll-like receptor (TLR) signaling through TLR2/6 and TLR4 is essential for the protective benefit of B cells in vivo, while B cell-specific deletion of...
Paper Details
Title
B cells support the repair of injured tissues by adopting MyD88‐dependent regulatory functions and phenotype
Published Date
Nov 18, 2021
Journal
Volume
35
Issue
12
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Notes
History